HIV mutations

Question 1

M184V increases RESISTANCE to

Answer 1

lamivudine , emtricitabine

Question 2

M184V increases SUSCEPTIBILITY to

Answer 2

efavirenz, zidovudine, tenofovir, and etravirine

Question 3

Q148H/R/K

Answer 3

resistant to integrase inhibitors

*can give BID dolutegravir

Question 4

I50L

Answer 4

resistant to atazanavir

Question 5

K65R increases RESISTANCE to

Answer 5

tenofovir, abacavir, didanosine, lamivudine, and emtricitabine

Question 6

K65R increases SUSCEPTIBILITY to

Answer 6

atazanavir

Question 7

K103N

Answer 7

resistant to efavirenz and nevirapine

*can still use etravirine

Question 8

Y181C

Answer 8

resistant to nevirapine (and other NNRTIs)

Question 9

E138K

Answer 9

resistant to rilpivirine (and other NNRTIs)

Question 10

K101E

Answer 10

resistant to rilpivirine (and other NNRTIs)

Question 11

N155H

Answer 11

resistant to raltegravir and elvitegravir

Question 12

Y143C

Answer 12

resistant to raltegravir

Question 13

R263K

Answer 13

resistant to all integrase inhibitors

Question 14

Maraviroc needs this type of virus to be effective

Answer 14

R5

Question 15

M41L, D67N, K70R, L210W, T215Y, K219Q

Answer 15

TAMs - 4 or more leads to resistance to all NRTIs and NNRTIs