CMV mutations and drugs Flashcards
1
Q
UL97
A
serine/threonine kinase mutation
resistant to ganciclovir
2
Q
UL54
A
DNA polymerase mutation
resistant to ganciclovir, foscarnet, and cidofovir
3
Q
UL56
A
terminase mutation
resistant to letermovir
4
Q
ganciclovir & valganciclovir have activity against
A
CMV, HSV, VZV, HHV-6
5
Q
Acyclovir & valacyclovir have activity against
A
HSV, VZV, (CMV if very high dose)
6
Q
Famciclovir has activity against
A
HSV, VZV, (CMV if very high dose)
7
Q
letermovir has activity against
A
CMV (only used for ppx)
8
Q
foscarnet has activity against
A
CMV, HSV, VZV, and HHV-6
9
Q
cidofovir has activity against
A
CMV, HSZ, VZV, and HHV-6