CMV mutations and drugs Flashcards

1
Q

UL97

A

serine/threonine kinase mutation

resistant to ganciclovir

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2
Q

UL54

A

DNA polymerase mutation

resistant to ganciclovir, foscarnet, and cidofovir

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3
Q

UL56

A

terminase mutation

resistant to letermovir

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4
Q

ganciclovir & valganciclovir have activity against

A

CMV, HSV, VZV, HHV-6

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5
Q

Acyclovir & valacyclovir have activity against

A

HSV, VZV, (CMV if very high dose)

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6
Q

Famciclovir has activity against

A

HSV, VZV, (CMV if very high dose)

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7
Q

letermovir has activity against

A

CMV (only used for ppx)

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8
Q

foscarnet has activity against

A

CMV, HSV, VZV, and HHV-6

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9
Q

cidofovir has activity against

A

CMV, HSZ, VZV, and HHV-6

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