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MRCP Part 2 > HIV meds > Flashcards

HIV meds Flashcards

1
Q

What is the mechanism of action of maraviroc?

A

Entry inhibitor - binds to CCR5, preventing an interaction with gp41

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2
Q

What is the mechanism of action of enfuvirtide?

A

Entry inhibitor - binds to gp41, also known as a fusion inhbitor

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3
Q

What is the mechanism of zidovudine AZT?

A

NRTI

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4
Q

What is the mechanism of action of abacavir?

A

NRTI

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5
Q

What is the mechanism of action of didanosine?

A

NRTI

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6
Q

What is the action of lamivudine?

A

NRTI

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7
Q

What is the action of stavudine?

A

NRTI

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8
Q

What is the mechanism of action of zalcitabine?

A

NRTI

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9
Q

What is the mechanism of action of tenofovir?

A

NRTI

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10
Q

What is the general side effects of the NRTIs?

A

Peripheral neuropathy
Potentially fatal lactic acidosis
Severe hepatomegaly with steatosis

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11
Q

What are the side effects of tenofovir?

A

Most common side effects are gastrointestinal
Renal impairment and osteoporosis

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12
Q

What are the side effects of zidovudine?

A

Anaemia, myopathy, black nails

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13
Q

What are the side effects of didanosine?

A

Pancreatitis

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14
Q

What is the mechanism of action of nevirapine?

A

NNRTI

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15
Q

What is the mechanism of efavirenz?

A

NNRTI

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16
Q

What are the general side effects of NNRTI?

A

P450 enzyme interaction (nevirapine induces)
Rashes

17
Q

What are the side effects of efavirenz?

A

Nightmares

18
Q

What are the side effects of Abacavir?

A

Most concerning is a hypersensitivity reaction that can lead to fever, malaise, nausea and skin rash which can be very severe.

It is strongly associated with a specific allele at the human leukocyte antigen B locus, HLA-B*57:01

19
Q

What is the mechanism of action of indinavir?

A

Protease inhbitor

20
Q

What is the mechanism of action of nelfinavir?

A

Protease inhibitor

21
Q

What is the mechanism of action of ritonavir?

A

Protease inhibitor

22
Q

What is the mechanism of action of saquinavir?

A

protease inhibitor

23
Q

What are the general side effects of the protease inhibitors?

A

Diabetes, hyperlipidaemia, buffalo hump, central obesity, P450 enzyme inhbition

24
Q

What are the side effects of indinavir?

A

Renal stones, asymptomatic hyperbilirubinaemia

25
Q

What are the side effects of ritonavir?

A

Potent inhibitor of the P450 system

26
Q

What is the mechanism of action of raltegravir?

A

Integrase inhibitor

27
Q

What is the mechanism of action of elvitegravir?

A

Integrase inhbitor

28
Q

What is the mechanism of action of dolutegravir?

A

Integrase inhbitor

MRCP Part 2 (6 decks)

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