HIV meds Flashcards
What is the mechanism of action of maraviroc?
Entry inhibitor - binds to CCR5, preventing an interaction with gp41
What is the mechanism of action of enfuvirtide?
Entry inhibitor - binds to gp41, also known as a fusion inhbitor
What is the mechanism of zidovudine AZT?
NRTI
What is the mechanism of action of abacavir?
NRTI
What is the mechanism of action of didanosine?
NRTI
What is the action of lamivudine?
NRTI
What is the action of stavudine?
NRTI
What is the mechanism of action of zalcitabine?
NRTI
What is the mechanism of action of tenofovir?
NRTI
What is the general side effects of the NRTIs?
Peripheral neuropathy
Potentially fatal lactic acidosis
Severe hepatomegaly with steatosis
What are the side effects of tenofovir?
Most common side effects are gastrointestinal
Renal impairment and osteoporosis
What are the side effects of zidovudine?
Anaemia, myopathy, black nails
What are the side effects of didanosine?
Pancreatitis
What is the mechanism of action of nevirapine?
NNRTI
What is the mechanism of efavirenz?
NNRTI
What are the general side effects of NNRTI?
P450 enzyme interaction (nevirapine induces)
Rashes
What are the side effects of efavirenz?
Nightmares
What are the side effects of Abacavir?
Most concerning is a hypersensitivity reaction that can lead to fever, malaise, nausea and skin rash which can be very severe.
It is strongly associated with a specific allele at the human leukocyte antigen B locus, HLA-B*57:01
What is the mechanism of action of indinavir?
Protease inhbitor
What is the mechanism of action of nelfinavir?
Protease inhibitor
What is the mechanism of action of ritonavir?
Protease inhibitor
What is the mechanism of action of saquinavir?
protease inhibitor
What are the general side effects of the protease inhibitors?
Diabetes, hyperlipidaemia, buffalo hump, central obesity, P450 enzyme inhbition
What are the side effects of indinavir?
Renal stones, asymptomatic hyperbilirubinaemia
