HIV Drugs Part 2

Question 1

Abacavir adverese reaction

Answer 1

hypersensitivity (rash, fever, abdominal pain, shortness of breath)

Question 2

what must one screen for before putting patient on abacivir

Answer 2

HLA-B 5701

Question 3

Didanosine adverse reactions

Answer 3

peripheral neuropathy

Question 4

zidovudine adverse reactions

Answer 4

anemia

Question 5

stavudine ADR

Answer 5

peripheral neuropathy

Question 6

Adverse effects of integrase inhibitors

Answer 6

nausea, diarrhea, headache
pyrexia
CPK elevation

Question 7

what drugs are integrate inhibitors

Answer 7

Raltegracir
Elvitegravir
Dolutegravir

Question 8

what is the booster of all bosters

Answer 8

ritonavir

Question 9

protease inhibitors MOA

Answer 9

inhibit HIV-1 protease

Question 10

ritonavir is a booster that allows for what

Answer 10

lower doses and pill burden for several antivirals

Question 11

what is the hallmark side effect of all protease inhibitors

Answer 11

endocrine type side effects:
hyperlipidemia
fat maldistribution
insulineresistance/diabetes mellitus
osteonecrosis

Question 12

what are the two bosters

Answer 12

ratonavir

cobicistat

Question 13

what booster has antiviral activity

Answer 13

ritanovir

Question 14

what booster does not have antiviral activity

Answer 14

cobicistat

Question 15

what are the side effects of ritanovir

Answer 15

paresthesias
taste disturbances/anorexia
endocrine type

Question 16

what are the side effects of darunavir

Answer 16

rash
good for PI resistance virus
endocrine type

Question 17

what are the side effects of tipranivir

Answer 17

rash
hepatotoxicity
good for PI resistant virus
endocrine type

Question 18

why would one avoid efavirenz

Answer 18

teratogenic in nonhuman primates so avoid that in pregnancy

Question 19

what drugs should be avoided in pregnancy

Answer 19

nelfinavir

efavirenz

Question 20

what is recommended during labor if maternal HIV RNA is over 400 copies per mL

Answer 20

Zidovudine

Question 21

what is recommended for all HIV pregnant women (regardless of CD4 count, viral load, clinical status)

Answer 21

combination ART (anti-retroviral therapy)

Question 22

post exposure prophylaxis (PEP) should be started when and taken for how long

Answer 22

2 hours after exposure

take it for 28 days

Question 23

Post Exposure Prophylaxis regimine includes

Answer 23

Raltegravir and Truvada

Question 24

what HIV therapy drugs have peripheral neuropathy as side effects

Answer 24

didanosine

stavudine

Question 25

what drug has bone marrow suppression as a side effect

Answer 25

zidovudine

Question 26

what drug must you screen for HLA B5701 for

Answer 26

Abacavir

Question 27

what drugs cause rashes

Answer 27

NNRTIs (delvaridine, efavirenz, etravirine, nevirapine)

Question 28

what drug causes pancreatitis

Answer 28

didanosine

Question 29

what drugs cause lactic acidosis

Answer 29

``` tenofovir all NRTIs (abavacir, didanosine, emtricitabine, lamivudine, stavudine, zidovudine) ```

Question 30

what drugs cause lipid abdormalities

Answer 30

protease inhibitors (atazanvir, darunavir, eosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir)

Question 31

what drugs have cross sensitivity with sulfa rash

Answer 31

darunavir, tipranivir

Question 32

what drugs cause hyperbilirubinemia leading to jaundice

Answer 32

atazanavir | indinavir

Question 33

what drugs cause paresthesias

Answer 33

fosamprenavir | ritonavir

Question 34

what drug causes nephrolithiasis

Answer 34

indinavir

Question 35

what drugs cause insulin resistance/ diabetes mellitus

Answer 35

protease inhibitors (atazanvir, darunavir, eosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir)

Question 36

what drug causes injection site reaction/irritation

Answer 36

enfubirtide

Question 37

what drug is restricted to patients with CCR5 tropic virus

Answer 37

maraviroc

Question 38

what drug is restricted to treatmeant experienced HIV patients and causes CPK election/pyrexia

Answer 38

raltegravir