HIV Drugs Flashcards
what class of HIV drugs inhibit the binding of HIV to the host cell
CCR5 antagonist
what class of drugs inhibit the fusion of HIV to the outside of the cell
fusion inhibitors
what class(es) of drugs inhibit reverse transcription step of HIV life cycle
NNRTI and NRTI
what class of drugs inhibit the HIV genome is integrated into hosts nucleus
Integrase inhibitors
what class of drugs inhibit viral assembly and maturation
protease inhibitors
what drugs are NRTIs
Abacabir Didanosine Emtricitabine Lamivudine Stravudine Tenofovir Zidovudine
what drugs are NNRTIs
Delavirdine Efavirenz Etravirine Nevirapine Rilpivirine
What drugs are protease inhibitors
Atazanavir Darunavir Fosamprenavir Indinavir Lopinavir Nelfinavir Ritonavir Saquinavir Tipranavir
what drugs are integrase inhibitors
Dolutegravir
Elvitegravir
Raltegravir
What drugs are fusion inhibitors
Enfuvirtide
what drugs are CCR5 antagonists
Maraviroc
what are the goals of Antiretroviral therapy
reduce HIV related morbidity and prolong survival
improve quality of life
restore and preserve immunologic function
maximally and durably suppress HIV viral load
Prevent vertical HIV transmission
what is the major clinical indicator of immunocompetence in HIV infections
CD4 T cell count
usually single most important decision to initiate therapy
how often is CD4 T cell count reassess in HIV patients
every 3-6 months
some main AIDS defining indications are
Candidiasis CMV Mycobacterium avium complex Wasting syndrome caused by HIV Pneumocystis carinii pneumonia Cryptococcus Kaposi's sarcome Toxoplasmosis of the brain
CD4 count less than 200 with pneumocystis carinii (jirveci) pneumonia what would the treatment be
Bactrim DS
CD4 count less than 100 toxoplasmosis what would the treatment be
Bactrim DS
CD4 count less than 50 with MAC what would treatment be
Azithromycin
CD4 count less than 50 with CMV what would treatment be
ganciclovir
what are the benefits of early intervention
maintenance of higher CD4 count
prevention of irreversible damage to immune system
decreased risk of HIV complications
decreased risk of non-opportunistic conditions
if considering nevirapine what does one need to consider
gender and pretreatment CD4 count
females greater than 250 makes greater than 400 (higher risk of liver toxicity)
if considering abacavir what does one need to consider
allergy screening with HLA B5701
co-morbititeis of HIV therapy are
pregnancy
TB
when giving Complera what would one have to watch and what would you give instead
high viral load (over 100k)
give atripla first then when viral count goes down give complera
