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HIV > HIV ART > Flashcards

HIV ART Flashcards

1
Q

what type of drugs target reverse transcritase

A

NRTIs (nucleoside/nucleotide reverse transcriptase inhibitors)
NNRTIs (non-nucleoside reverse transcriptase inhibitors)

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2
Q

Entry inhibitors are divided into two groups

A

Fusion inhibitors (Enfuvirtide -T20 or Fuzeon) given as twice daily subcutaneous and CCR5 antagonists (Maraviroc - MVC or Celsentri)

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3
Q

What are the four NNRTIs (non nucleoside reverse transcriptase inhibitors)

A

Nevirapine (Viramune)
Efavirenz (Stocrin)
Etravirine (Intelence)
Rilpivirine (Edurant)

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4
Q

What are the NtRTIs (nucleotide reverse transcriptase inhibitors) and the four combination formulas

A

Anything with Tenofovir in it

Tenofovir disoproxil fumarate (TDF) (Viread) and Tenofovir alafenamide (TAF)
Combinations are
Truvada (Tenofovir and Emtricitabine)
Atripla (Tenofovir and Emtricitabine and Efavirenz)
Eviplera (Tenofovir and Emtricitabine and Rilpivirine)
Stribild (Tenofovir and Emtricitabine, Elvitegravir and cobicistat)

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5
Q

Name the six NRTIs (nucleoside reverse transcriptase inhibitors)

A 
Abacavir (ABC) Ziagen
Didanosine (DDI) Videx
Emtricibine (FTC) Emtriva
Lamivudine (3TC) 
Stavudine (d4T) Zerit
Zidovudine (AZT) Retrovir
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6
Q

Name the three combinations of NRTIs (nucleoside reverse transcriptase inhibitors)

A

Abacavir & Lamivudine (Kivexa)
Abacavir & Lamivudine & Zidovudine (Trizivir)
Lamivudine & Zidovudine (Combivir)

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7
Q

name the four NNRTIs (non-nucleoside reverse transcriptase inhibitors)

A

Efavirenz (EFV) Stocrin
Etravirine (ETR) Intelence
Nevirapine (NVP) Viramune
Rilpivirine (RPV) Edurant

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8
Q

Name the eight Protease inhibitors (PIs)

A 
Atazanavir (ATV) Reyataz
Darunavir (DRV) Prezista
Fosamprenavir (FPV) Telzir
Indinavir (IDV) Crixivan
Lopinavir (& Ritonavir) (LPV/r) Kaletra
Ritonavir (RTV) Norvir
Saquinavir (SQV) Invirase
Tipranavir (TPV) Aptivus
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9
Q

Name two Intergrase inhibitors

A

Raltegravir (RAL) Isentress

Dolutegravir (Tivicay)

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10
Q

what are the six targets for cART in the replication of HIV

A 
Entry
Reverse transcription
Intergration
Transcription
Virus assembly and production
Protease processing
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HIV (3 decks)

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