hiv and HCVdrugs

Question 1

list all the reverse transcriptase inhibitors you know?

Answer 1

Ziduvudine, lamivudine, tenofovir
Efavirenz, nevirapine

Question 2

side effect of ziduvudine

Answer 2

anemia and myopathy

Question 3

side effect of tenofovir

Answer 3

acute tubular necrosis

Question 4

side effect of nevirapine

Answer 4

rash and hepatitis

Question 5

another use of ziduvudine?

Answer 5

used as a prophlaxys to prevent fetal transmission of HIV

Question 6

list 4 integrase inhibitors you know?

Answer 6

BERD: bictegrvir, elvtegravir, raltegravir dolutegravir

Question 7

list 4 protease inhibitors you know

Answer 7

LARD : lopinavir, atazanavir, ritonavir, darunavir

Question 8

side effect of protease inhibitors

Answer 8

they cause metabolic side effect like : hyperglycemia, hyperlipidemia, and lipid dystrophy

Question 9

side effect of ritonavir

Answer 9

inhibits cyp450
which will increase other drug concentration

Question 10

list the two fusion or entry inhibitors?

Answer 10

Enfuviritde and maraviroc
enfuviritide bind to gp 41, maraviroc binds to CCR5 receptor that binds to gp120

Question 11

side effect of the fusion inhibitors

Answer 11

Skin reaction at injection sites.
Enfuvirtide inhibits fusion.
Maraviroc inhibits docking.

Question 12

pre exposure prophlaxis

Answer 12

tenofovir + emtricitabine

Question 13

list all NS5A inhibitors
you know and side effect?

Answer 13

Ledipasvir, Ombitasvir, Velpatasvir
headache and diarrhea

Question 14

list all NS5B inhibitor you know and side effect?

Answer 14

Sofosbuvir, Dasabuvir prevent viral replication
may lead to Fatigue, headache

Question 15

list all protease inhibitors/NS3/4A inhibitors you know and side effect?

Answer 15

Grazoprevir: headache, fatigue
Simeprevir: photosensitivity reactions, rash

Question 16

what you know about Ribavirin

Answer 16

Inhibits synthesis of guanine nucleotides by
competitively inhibiting IMP dehydrogenase.
may lead to Hemolytic anemia, severe teratogen