HIV and Aids Flashcards
1
Q
normal CD4 count? AIDS CD4 count?
A
normal >500
AIDS <200
2
Q
natural history of HIV?
A
acute infection - seroconversion asymptomatic HIV related illness AIDS defining illness Death
3
Q
Primary HIV / Seroconversion
A
around 30-60% patients have seroconversion which is when HIV antibodies first develop
abrupt onset 2-4w after exposure lasting 1-2w
flu like illness
4
Q
what is the commonest late stage (AIDS) infection?
A
pneumocystis jiroveci pneumonia
5
Q
pneumocystis jiroveci pneumonia classical history?
A
dry cough and increasing breathlessness over several weeks
6
Q
pneumocystis jiroveci pneumonia investigations?
A
CXR
induced sputum or bronchoscopy for PCR
7
Q
pneumocystis jiroveci pneumonia treatment? prophylaxis?
A
cotrimoxazole or pentamidine
get CD4 >200
8
Q
anti-retroviral drug actions? (4)
A
entry inhibitors
reverse transcription inhibitors
integrase inhibitor
protease inhibitors
