HIV/AIDS Flashcards
***Focus on ______***
Pharmacotherapy awareness
(whatever the fuck that means…)
_______ block CD4 receptors on the surface of certain immune cells that HIV needs to enter the cells.
Post-attachment inhibitors
8 classes of HIV medications
(PPP)
(NN)
(CIF)
- PE: Pharmacokinetic Enhancer
- PI: Protease Inhibitor
- PAI: Post Attachment Inhibitor
- NNRTI: Non-nucleoside Reverse Transcriptase Inhibitor
- NRTI: Nucleoside Reverse Transcriptase Inhibitor
- CA: CCRS Antagonists
- INSTI: Integrase Inhibitor
- FI: Fusion Inhibitor
Some of the barriers to Adherence to Antiretroviral Therapy
- Lack of education/understanding of HIV disease
- Denial / Anxiety
- Depression / Mental illness
- Substance abuse
- Medication SE
- Complicated dosing regimen
- Poor social situation
- Lack of family / community support
- Inadequate health insurance
- Poor clinician - patient relationship
MOA of which drug class?
- NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself
NRTIs: Nucleoside Reverse Transriptase Inhibitors
- Abacavir
- Tenofovir
- Emtricitabine
- Lamivudine
- Zidovudine
MOA of which drug class?
- Bind to and later alter reverse transcriptase, an enzyme HIV needs to make copies of itself
NNRTIs: Non-Nucleoside Reverse Transcriptase Inhibitors
- Doravirine
- Etravirine
- Rilpivirine
- Efavirenz
- Nevirapine
MOA of which drug class?
- Block HIV protease, an enzyme HIV needs to make copies of itself
PIs: Protease Inhibitors
- Atazanavir
- Darunavir
- Fosamprenavir
- Ritonavir
- Saquinavir
- Tipranavir
(All end in AVIR)
MOA of which drug class?
- Block HIV from entering the CD4 cells of the immune system
Fusion Inhibitors
- Enfuvirtide
MOA of which drug class?
- Block coreceptors on the surface of certain immune cells that HIV needs to enter the cells
CCR5 Antagonists
- Maraviroc
MOA of which drug class?
- Block HIV integrase, an enzyme HIV needs to make copies of itself
Integrase Inhibitors
- Dolutegravir
- Raltegravir
MOA of which drug class?
- Block CD4 receptors on the surface of certain immune cells that HIV needs to enter the cells
Post-Attachment Inhibitors
- Ibalizumab-uiyk
MOA of which drug class?
- Used in HIV treatment to increase the effectiveness of an HIV medicine included in an HIV regimen
Pharmacokinetic Enhancers
- Cobicstat
What are the 5 Combination HIV Medications?
- Triumeq: Abacavir, dolutegravir, lamivudine
- Trizivir: Abacavir, lamivudine, zidovudine
- Epzicom: abacavir & lamivudine
- Evotaz: Atazanavir, cobicistat
- Biktarvy: bictegravir, emtricitabine, tenofovir, alafenamide
(TTEEB)
Key Concepts:
- HIV infects cells expressing CD4 receptors, what does CD4 stand for?
- What are the 5 types of cells infected?
- Infection is via an interaction between glycoprotein 160 (gp 160) on HIV with CD4 (primary interaction) and _________ (secondary interactions) present on the surfaces of these cells
- Cluster of Differentiation 4
- T-helper lymphocytes
- Monocytes
- Macrophages
- Dendritic cells
- Brain Microglia
- Chemokine Co-receptors
Key Concepts:
- Hallmark of UNTREATED HIV infection is _________ and _________.
- 2 Current goal of combination anti-retroviral therapy (ART) ?
- Profound CD4 T-lymphocyte depletion & Severe immunosuppression
- Suppression of HIV replication
- Increase in CD4 lymphocytes
