Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SG - Pharm 4 > Derm 2 > Flashcards

Derm 2 Flashcards

1
Q

Corticosteroids

  • _____ effects on epidermis
  • MOA in diseases w/ increased cell turnover such as ____.
  • Minimally absorbed following application to _____ skin.
  • Occlusion w/ plastic wrap leads to ____ increase in absorption.
  • Penetration increases in ____ skin such as ____ and exfoliative diseases.
A
  • Antimitotic
  • psoriasis
  • normal
  • ten-fold
  • inflamed skin / atopic dermatitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Corticosteroid Selection

  • ____ are used for severe dermatoses over non-facial and non-intertriginous areas (scalp, palms, soles, thick plaques on extensor surfaces)
A

Super high potency (class 1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Corticosteroid Selection

  • ______ are appropriate for mild to moderate non-facial and non-intertriginous areas
  • Are okay to use on flexural surfaces for limited periods
A

Medium to high potency (class 1, 2, 3, 4, 5)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Corticosteroid Selection

  • ______ can be used for large areas and on thinner skin
  • Face, eyelid, genital, intertriginous areas
A

Low potency (class 6 & 7)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What duration of therapy for Super High Potency Corticosteroids?

A

< 3 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What duration of therapy for medium - high potency corticosteroids?

A

< 6 - 8 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What duration of therapy for low potency corticosteroids?

A

1 - 2 weeks to avoid skin atrophy, telangiectasia, and steroid induced acne

(SE are rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location
  • Clobetasol proprionate cream or ointment
A
  • Class 1
  • Super High Potency
  • Tx for < 3 weeks
  • Scalp, palms, soles, thick plaques on extensor surfaces
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Betamethasone diproprionate cream

Fluocinomide cream, gel, ointment, solution

A
  • Class 2
  • Medium - high
  • < 6-8 weeks
  • non-facial / non-intertriginous areas
  • okay on flexural surfaces for limited periods)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Betamethasone diproprionate cream

Betamethasone diproprionate lotion

Betamethasone valerate ointment

A
  • Class 3
  • Medium - high
  • < 6 - 8 weeks
  • non-facial and non-intertriginous areas
  • Okay to use on flexural surfaces for limited periods
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Fluocinolone acetonide ointment

Triamcinolone acetonide cream or ointment

A
  • Class 4
  • Medium - high
  • < 6 - 8 weeks
  • non-facial and non-intertriginous areas
  • Okay to use on flexural surfaces for limited periods
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Fluocinolone acetonide cream

A
  • Class 5
  • Medium - high
  • < 6 - 8 weeks
  • non-facial and non-intertriginous areas
  • Okay to use on flexural surfaces for limited periods
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Triamcinolone acetonide cream

A
  • Class 6
  • Low Potency
  • 1 - 2 weeks
  • Large areas / thinner skin
  • face, eyelid, genital, intertrignous areas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q
  • What class of corticosteroid?
  • Which potency?
  • Duration
  • Location

Hydrocortisone ointment

A
  • Class 7
  • Low Potency
  • 1 - 2 weeks
  • Large areas / thinner skin
  • face, eyelid, genital, intertrignous areas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 5 “Systemic” SE of Topical Glucocorticoid Therapy?

A
  • Suppression of hypothalamic-pituitary-adrenal axis
  • Cushing’s Syndrome
  • Pseudotumor cerebri
  • Growth retardation
  • Sodium retention and edema
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the 5 “Ocular” SE of Topical Glucocorticoid Therapy?

A
  • Cataract
  • Glaucoma
  • Retarded healing of corneal abrasion
  • Extension of herpetic infection
  • Increased susceptibility to bacterial and fungal infection
17
Q

What are the 7 “Cutaneous” SE of Topical Glucocorticoid Therapy?

A
  • Atrophy (both epidermal and dermal)
  • Striae distensae
  • Telangiectasias, purpura (senile type) and ecchymosis
  • Hypopigmentation
  • Retardation of wound healing
  • Contact allergic dermatitis - glucocorticoid-induced (rare), vehicle-induced (common)
  • Topical glucocorticoid “habituation”
18
Q

Contact dermatitis

  • Allergic contact dermatitis to new eye shadow.
  • What is the treatment?
A
  • Desonide 0.5% cream (topical corticosteroid) for limited period

Twice daily for 1 week, followed by once daily for 1-2 weeks, then discontinue

19
Q

Dermatitis of Eyelid

Which drug?

  • Too potent, class 1
A

Clobetasol ointment 0.05%

20
Q

Dermatitis of Eyelid

Which drug?

  • Too potent, gels have alcohol and may burn on the eyelid, class 2
A

Flucoinonide gel 0.05%

21
Q

Dermatitis of Eyelid

Which drug?

  • treats fungal infection
A

Ketoconazole cream 2%

22
Q

What are the 7 different antibacterial agents?

A
  • Bacitracin
  • Mupirocin
  • Polymyxin B
  • Neomycin
  • Gentamicin
  • Topical abx in acne
  • Oral abx in acne
23
Q

Which antibacterial agent?

  • Active against gram + organisms (Strep, staph, pneumo)
  • Compounded in an ointment base alone or in combo w/ neomycin, polymyxin B, or both
  • Poorly absorbed through skin
    • systemic toxicity is rare
    • allergic contact dermatitis is frequent (neomycin most likely)
A

Bacitracin

24
Q

Which Antibacterial Agent?

  • Active against gram + infections (MRSA)
  • ADE: stinging, burning, pruritis, HA
  • Cream or ointment
A

Mupirocin

25
Q

What makes up the Triple Antibiotic Ointment?

A
  • Polymyxin B
  • Neomycin
  • Bacitracin
26
Q

Which drug in the TAO? (Triple Antibiotic Ointment)

  • Effective against gram negative organisms
    • p aeruginosa
    • Enterobacter
    • E. coli
A

Polymyxin B

27
Q

Which drug in the TAO? (Triple Antibiotic Ointment)

  • Active against aerobic Gram Positive and Gram Negative Bacilli
    • S aureus
    • E. coli
  • Sensitization as high as 30% (contact dermatoses)
A

Neomycin (an aminoglycoside)

28
Q

Which drug in the TAO? (Triple Antibiotic Ointment)

  • Primarily active against the Gram Positive bacteria
    • S aureus
    • streptococci
A

Bacitracin

29
Q

What severity of acne?

  • <20 comedones
  • <15 inflammatory lesions
  • <30 total lesions
A

Mild

30
Q

What severity of acne?

  • 20-100 comedones
  • 15-50 inflammatory lesions
  • 30-125 total lesions
A

Moderate

31
Q

What severity of acne?

  • >5 cysts
  • >100 total comedone count
  • >50 total inflammatory lesion count
  • >125 total lesions
A

Severe

32
Q

Tx for comedones

A

Tretinoin

33
Q

Tx for mild inflammatory acne

A
  • topical retinoid alone
  • topical benzoyl peroxide alone
  • and/or topical abx
34
Q

Tx for moderate acne?

A
  • Topical Retinoid + Topical Benzoyl Peroxide
  • +/- topical abx
  • Consider
    • oral abx
    • derm referral
    • hormonal therapy for females
35
Q

Tx for severe acne

A
  • Topical Retinoid + Topical Benzoyl Peroxide + Oral Abx
  • +/- topical abx
  • Consider:
    • oral isotretinoin
    • derm referral
    • hormonal therapy for females
36
Q

Tx for Cystic Acne

A

Intralesional triamcinolone

37
Q

Benzoyl Peroxide is converted to ____ within the epidermis and dermis.

A

Benzoic Acid

38
Q
  • What are the 2 topical abx for mild to mod inflammatory acne?
  • What are the 2 topical abx for Rosacea?
A
  • Mild to Mod inflammatory Acne: Clindamycin & Erythromycin
  • Rosacea: Metronidazole & Sulfacetamide
39
Q
A

SG - Pharm 4 (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions