HIV AIDS

Question 1

what allows HIV to replicate constantly in normal adults

Answer 1

• temporal control of gene expression, early adn late genes
• additional gene products, which protect the virus against innate and acquired immune antiviral responses
• extensive glycosylation of the Env protein
• extensive genetic variation in env and other proteins

Question 2

what does constant replication lead to?

Answer 2

extensive genetic variation of the virus and to eventual loss of Cd4 cells, inevitably leading to AIDS

Question 3

what process in the body can foil efforts to cure the disease

Answer 3

-a few infected cells enter a restin state which can last for decades

Question 4

what protein in the HIV genome is designed to evade the immune system?

Answer 4

Env

-there are about 24 glycosylation sites

Question 5

Tat

Answer 5

-protein that interacts with the Tar region of the nascent RNA transcript, leading to the alteration of RNA pol via phosphorylation and allowing continuation of transcription to the end of the provirus