HIV

Question 1

A mutation in CCR-5 receptor leading to inactivation results in what?

Answer 1

Individuals homozyous for this CCR-5 mutation are very resistant to HIV infection
(this is due to reduced spread rather than enhanced immune response)

Question 2

Fuzeon

Answer 2

Fusion inhibitor, blocks the the entry of HIV into cells. Rationally designed to mimic components of GP41

Question 3

Maraviroc

Answer 3

CCR5 inhibitor - blocks attachment of HIV to CCR5 halting HIV replication

Question 4

Raltgravir

Answer 4

Integrase inhibitor

Virus has to intergrate its genetic materia into the the host cells, this replication is accomplished by an enzyme called intergrase

Question 5

what is highly active anti-retroviral therapy? (HAART)

Answer 5

HAART generally takes 3 different anti-retro viral drugs from at least 2 different classes

aims to reduce incidence of resistance and side effects by using lower dose