HIV 2 (PIs, fusion & entry inhibitors, integrase strand transfer inhibitor)

Question 1

Protease inhibitors (PIs) (6 drugs)

Answer 1

Saquinavir
Lopinavir
Ritonavir
Atazanavir
Darunavir
Fosamprenavir

Question 2

PIs - MOA

Answer 2

Bind HIV protease and inhibits proteolytic activity. Production of immature, noninfectious viral particles.

Question 3

PIs - adverse effects

Answer 3

Lipodystrophy
DM
Liver dysfunction

Question 4

PI used for boost in therapy, and mechanism of this boost

Answer 4

Ritonavir. It inhibits metabolism of other PIs

Question 5

PI with highest incidence of adverse effects

Answer 5

Ritonavir

Question 6

Which PIs are preferred for HIV pt? (2 drugs)

Answer 6

Atazanavir

Darunavir

Question 7

Fusion and entry inhibitors (2 drugs)

Answer 7

Maraviroc

Enfuvirtide

Question 8

Fusion and entry inhibitors - indications

Answer 8

HIV by drug-resistant strains

Question 9

Enfuvirtide - adm

Answer 9

Subcutaneously

Question 10

How do the fusion and entry inhibitors interact with each other?

Answer 10

Synergistic activity

Question 11

Integrase strand transfer inhibitor (1 drug)

Answer 11

Raltegravir

Question 12

Raltegravir - MOA

Answer 12

Prevents DNA strand transfer by binding integrase

Question 13

Maraviroc - MOA

Answer 13

Binds to CCR5 and prevents entry of HIV-1 to cells.

Question 14

Enfuvirtide - MOA

Answer 14

Binds to HIV glycoprotein 41 and block the fusion process

Question 15

Which HIV-drug can be safely used in children?

Answer 15

Enfuvirtide