HIV Flashcards
phases of the life cycle
step 1: binding/ attatchment. travel to cd4 cell. travels into cell via cxcr4 and cxcr5
drugs
Maraviroc(Selzentry). prevents drug from entering throughccr5. must do test to make sure the type of hiv the pt has only allows entry thorugh ccr5 and not cxcr4 or mix
other drugs tht deal w cell binding and attatchment
Ibalizumab (trogarzo)
fostemsavir (rukobia)
Step 2 of life cycle
Fusion.. fuse intocell and spill its content into cellk
enfuviritide (fuzeaon)
FU OR FUSION
horrible side effects. horrible in kection site nodules sq injection
step 3
converison into hiv dna
NRTIS’s- compete for active site on nucleotides to stop replication
NNRTI’s-bind allosterically to stop process of replication
step4
hiv gets incorporated into host cell dna
Instis- integrase inhibitors
step 5 and 6
replication and assembly
no drugs for that stage
stage 7
budding and maturation
protease inhibitors
NRTI’s key agents
abacavir
emtricitabine
lamivudine
tenofavit disoproxil fumarate(TDF)
tenofavir alafenamide (TAF)
NNRTI’s
efaVIRinz
rilpIVIrine
Protease inhibitors
END IN NAVIR
integrase inhibitors
end in gravir
recommended intial ART regimens
INSTI+NRTI backbone usually composed of 2.
except
Dolutegravir /Lamivudine. reserved for viral load <500,000 copies, noi known hep b coinfection and genotype testing results are available
brand name for bictegravir/ emtrecitabine/ TAF
biktarvy
dolutegravir/ abacavir/ lamivudine
triumeq
dolutegravir/lamivudine
dovato
Dolutegravir+Emtricitabine+TDF)
Tivicay +truvada
dolutegravir + Emtricitabine +TAF
Tivicay+Descovy
Raltegravir + emtricitabine/ TDF-
isentress+ truvada
raltegravir +emtricitabine/ tAF
ise tress+descovy
rilpivirine/emtricitabine/TDF
complera
rilpivirine/emtricitabine/TAF
Odefsey
crc
other combo products
insti-based 4 pill combos: GEnvoya(has TAF)
stribild (tdf): take w food.
if it contains TDF, crcl cut off to start is <70 or 50.
if contains TAF, crcl cut off <30.
take all weird ocmbos w food except
atripla
efavirinz, emtricitabine, tdf
toxicities for nrtis
lactic acidosis
hepatomegaly
co-infected w hepb? dont stop abruptly
abacavir-hlab71
tenof-
nephro,osteomalacia/porosis, fanconi syndrome
instis must know
gravirs
bictegravir/dolutegravir:kncrease in scr
raltegravir: rabdo
dolutergavir: hypersensitiivty
seperate from
NNRTI’s:
bbw hepatotoxicity
avoid strong cyp ionducers
efavirinz: psychioatriac effects
take on empty stomach
