HIV

Question 1

phases of the life cycle

Answer 1

step 1: binding/ attatchment. travel to cd4 cell. travels into cell via cxcr4 and cxcr5

drugs
Maraviroc(Selzentry). prevents drug from entering throughccr5. must do test to make sure the type of hiv the pt has only allows entry thorugh ccr5 and not cxcr4 or mix

other drugs tht deal w cell binding and attatchment
Ibalizumab (trogarzo)
fostemsavir (rukobia)

Question 2

Step 2 of life cycle

Answer 2

Fusion.. fuse intocell and spill its content into cellk

enfuviritide (fuzeaon)
FU OR FUSION
horrible side effects. horrible in kection site nodules sq injection

Question 3

step 3

Answer 3

converison into hiv dna
NRTIS’s- compete for active site on nucleotides to stop replication
NNRTI’s-bind allosterically to stop process of replication

Question 4

step4

Answer 4

hiv gets incorporated into host cell dna

Instis- integrase inhibitors

Question 5

step 5 and 6

Answer 5

replication and assembly
no drugs for that stage

Question 6

stage 7

Answer 6

budding and maturation

protease inhibitors

Question 7

NRTI’s key agents

Answer 7

abacavir
emtricitabine
lamivudine
tenofavit disoproxil fumarate(TDF)
tenofavir alafenamide (TAF)

Question 8

NNRTI’s

Answer 8

efaVIRinz
rilpIVIrine

Question 9

Protease inhibitors

Answer 9

END IN NAVIR

Question 10

integrase inhibitors

Answer 10

end in gravir

Question 11

recommended intial ART regimens

Answer 11

INSTI+NRTI backbone usually composed of 2.
except
Dolutegravir /Lamivudine. reserved for viral load <500,000 copies, noi known hep b coinfection and genotype testing results are available

Question 12

brand name for bictegravir/ emtrecitabine/ TAF

Answer 12

biktarvy

Question 13

dolutegravir/ abacavir/ lamivudine

Answer 13

triumeq

Question 14

dolutegravir/lamivudine

Answer 14

dovato

Question 15

Dolutegravir+Emtricitabine+TDF)

Answer 15

Tivicay +truvada

Question 16

dolutegravir + Emtricitabine +TAF

Answer 16

Tivicay+Descovy

Question 17

Raltegravir + emtricitabine/ TDF-

Answer 17

isentress+ truvada

Question 18

raltegravir +emtricitabine/ tAF

Answer 18

ise tress+descovy

Question 19

rilpivirine/emtricitabine/TDF

Answer 19

complera

Question 20

rilpivirine/emtricitabine/TAF

Answer 20

Odefsey

crc

Question 21

other combo products

Answer 21

insti-based 4 pill combos: GEnvoya(has TAF)
stribild (tdf): take w food.

if it contains TDF, crcl cut off to start is <70 or 50.

if contains TAF, crcl cut off <30.

Question 22

take all weird ocmbos w food except

Answer 22

atripla

efavirinz, emtricitabine, tdf

Question 23

toxicities for nrtis

Answer 23

lactic acidosis
hepatomegaly
co-infected w hepb? dont stop abruptly

abacavir-hlab71

tenof-
nephro,osteomalacia/porosis, fanconi syndrome

Question 24

instis must know

Answer 24

gravirs

bictegravir/dolutegravir:kncrease in scr

raltegravir: rabdo
dolutergavir: hypersensitiivty

seperate from

Question 25

NNRTI’s:

Answer 25

bbw hepatotoxicity
avoid strong cyp ionducers
efavirinz: psychioatriac effects
take on empty stomach