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infectious disease > HIV > Flashcards

HIV Flashcards

1
Q

Abacavir

A

Abbreviation: ABC
Brand: Ziagen
Class: NRTI

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2
Q

Abacavir BBW

A
  • Screen for the HLA-B*5701 allele before starting (+ is contraindicated)
  • Hypersensitivity reactions (fever, rash, fatigue, malaise, GI, N/V/D, ab pain)
  • Respiratory symptoms (dyspnea cough)
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3
Q

Abacavir contraindications

A
  • Hypersensitivity to abacavir
  • moderate to severe hepatic impairment
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4
Q

Abacavir Warnings

A
  • caution in CVD due to possible increase risk of MI, Lactic acidosis and severe hepatomegaly with steatosis
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5
Q

Abacavir SE

A

N/V, HA, Increase LFT, hyperlipidemia

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6
Q

Abacavir Notes

A

-caution with alcohol
-Warning card (summarizing symptoms of hypersensitivity required)
-ABC/lamivudine with either efavirenz or atazanavir + ritonavir should not be used in patients with pre treatment HIV viral load > 100,000 copies/ml

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7
Q

Lamivudine

A

Abbreviation: 3TC
Brand: Epivir
Class: NRTI

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8
Q

Lamivudine BBW

A

-Do not use epivir-HBV for TXT of HIV (contains lower dose of lamivudine)
-can result in HIV resistance
-severe exacerbation of Hep B (HBV) can occur when drug is discontinued in patients with HBV

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9
Q

Lamivudine Warnings

A

-lactic acidosis
-severe hepatomegaly with steatosis

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10
Q

Lamivudine SE

A

HA, N/V/D, fatigue, insomnia, myalgias, increase LFT

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11
Q

Lamivudine monitoring

A

LFT, renal function, HBV status prior to initiation

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12
Q

Lamivudine Notes

A
  • avoid combining with emtricitabine (antagonists interaction as both are cytosine analogs
    -Has activity against HBV
    -In HIV/HBV co infection must dose lamivudine at the higher HIV TXT dose found in Epivir and symfi (epivir =/= epivir HBV)
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13
Q

Emtricitabine

A

Abbreviation: FTC
Brand: Emtriva
Class: NRTI

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14
Q

Emtricitabine BBW

A

severe exacerbation of Hep B (HBV) can occur when drug is discontinued in patients with HBV
-Truvada for pre exposure ppx only for patients confirmed to be HIV negative prior to initiating and Q3 months

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15
Q

Emtricitabine warnings

A

-lactic acidosis
- hepatomegaly with steatosis

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16
Q

Emtricitabine SE

A

N/V/D, rash, dizziness, HA, insomnia, hyperpigmentation in palmes and soles
- increase CPK and LFT

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17
Q

Emtricitabine Monitoring

A

LFTS
Renal function
HBV status prior to starting

18
Q

Emtricitabine notes

A
  • avoid combining with lamivudine (both are cytosine analogs)
    -avoid with triumeq, Epivir, Epivir-HBV
  • capsule and oral solution are not =
19
Q

Tenofovir disoproxil fumarate

A

abbreviation: TDF
Brand: Viread
Class: NRTI

20
Q

Tenofovir alafenamide

A

Abbreviation: TAF
Brand: HBV–> vemlidy
Class: NRTI

21
Q

Tenofovir- (disoproxil fumarate ) & (Alafenamide) BBW

A
  • all tenofovir containing products: Severe acute exacerbation of HBV can occur when the drug is D/C in patients with HBV infection
22
Q

Tenofovir (disoproxil fumarate ) & (Alafenamide) warnings

A
  • renal toxicity and/or fanconi syndrome, osteomalacia, and decrease bone mineral density
  • lactic acidosis and severe hepatomegaly with steatosis
23
Q

Tenofovir disoproxil fumarate SE

A

-N/V/D, HA, depression, renal impairment decrease bone density, and increase LFT, CPK

24
Q

Tenofovir Alafenamide SE

A

-nausea, decrease bone mineral density

25
Q

Tenofovir (disoproxil fumarate ) & (Alafenamide) monitoring

A

LFT, CBC, renal function , CPK, urinalysis, Ca, Po4, bone density, HBV status before start

26
Q

Tenofovir (disoproxil fumarate ) & (Alafenamide) Notes

A

-dispense in original containers
-avoid use with didanosine due to resistance and virologic failure and increase didanosine concentration
-consider vit D and calcium supplements

27
Q

Zidovudine

A

Abbreviation: ZDV
Brand: Retrovir
Class: NRTI

28
Q

Zidovudine BBW

A

-Hematologic toxicities (neutropenia and anemia)
-Prolonged use associated with myopathy and myositis
-lactic acidosis and hepatomegaly steatosis

29
Q

Zidovudine SE

A

-N/V, anorexia, skin/nail hyperpigmentation, myopathy, macrocytic anemia, lipoatrophy, increase LFT, insulin resistance, hyperlipidemia

30
Q

Zidovudine monitoring

A

-CBC, LFT, lipids, blood glucose, MCV

31
Q

Zidovudine notes

A

-Erythropoietin is indicated to manage zidovudine-induced anemia
-lipoatrophy: stavudine>zidovudine> other NRTI
-IV zidovudine should be in the setting of labor for HIV infected pregnant women, with HIV viral load >1,000 copes/ml or unknown viral load

32
Q

Stavudine

A

Abbreviation: d4T
Brand: Zerit
Class: NRTI

33
Q

Stavudine BBW

A
  • Pancreatitis in combo with didanosine
    -lactic acidosis and severe hepatomegaly with steatosis
34
Q

stavudine warnings

A

-neurologic syndromes including motor weakness, and hepatotoxicity

35
Q

Stavudine SE

A

-N/V/D, peripheral neuropathy, increase LFT, hyperbilirubinemia, lipoatrophy, pancreatitis, HA, insulin resistance/diabetes, hyperlipidemia

36
Q

Stavudine notes

A

Lipoatrophy: Stavudine>Zidovudine> other NRTI

37
Q

Didanosine

A

Abbreviation: ddl
Brand: Videx, Videx EC
Class: NRTI

38
Q

Didanosine BBW

A

-Pancreatitis
-Lactic acidosis and severe hepatomegaly with steatosis

39
Q

Didanosine Contraindications

A

allopurinol or ribavirin

40
Q

Didanosine warnings

A

-Noncirrhotic portal hypertension
retinal changes and optic neuritis

41
Q

Didanosine SE

A

-N/V/D, peripheral neuropathy, increase amylase, increase LFT, pruritus/rash

infectious disease (3 decks)

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