HIV Flashcards

1
Q

capsid inhibitor

A

lencapavir

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2
Q

gp120 inhibitors

A

fostemsavir
temsavir

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3
Q

CCR5 antagonist

A

maraviroc

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4
Q

NRTIs

A

lamivudine
emtricitabine
abacavir
tenofovir DF
tenofovir AF
zidovudine

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5
Q

NNRTIs

A

doravirine
efavirenz
rilpivirine

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6
Q

INSTIs

A

bictegravir
cabotegravir
dolutegravir
elvitegravir
raltegravir

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7
Q

protease inhibitors

A

atazanavir
darunavir
ritonavir

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8
Q

which drug requires tropism test

A

maraviroc

can use if CCR5-tropic disease

NOT if dual/mixed-tropic or CXCR4-tropic virus

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9
Q

which drug requires HLA-B*5701 testing

A

abacavir

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10
Q

which tenofovir causes renal, bone toxicity

A

DF

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11
Q

which regimen has an optional 4-week oral lead in period

A

injectable CAB+ RPV

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12
Q

laboratory testing parameters for HIV

A

HIV RNA: goal undetectable
CD4 count: goal >200 cells/mm3

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13
Q

when to initiate prophylaxis against opportunistic infections

A

CD4 count < 200 cells/mm3

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14
Q

when to initiate prophylaxis against PCP

A

CD4<200

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15
Q

when to initiate prophylaxis against toxoplasma

A

CD4<100

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16
Q

when to initiate prophylaxis against MAC

A

CD4<50 and not currently on ART

17
Q

vaccinations in PLWH

A

live attenuated influenza contraindicated
live replicating Mpox contraindicated

MMR and varicella contraindicated if CD4<200

18
Q

notable adverse effects of the integrase inhibitors

A

weight gain

19
Q

notable drug interactions for the integrase inhibitors

A

all: avoid or space out divalent cations (2h before or 6h after)

bictegravir: avoid rifampin

dolutegravir: max metformin dose is 500 bid

elvitegravir: no lovastatin or simvastatin. caution with steroids and contraceptives

20
Q

rilpivirine drug interactions

A

no PPIs
no dexamethasone

21
Q

protease inhibitor drug interactions

A

no lovastatin or simvastatin, max doses for other statins
caution with antiarrhythmics, contraceptives
avoid PPIs with atazanavir
caution with steroids: beclomethasone preferred

22
Q

PrEP options

A

TDF/FTC
TAF/FTC
LA CAB

23
Q

which PrEP treatment can cisgender women not get

24
Q

when opportunistic infection treatment is needed, when to start ART

A

within 2 weeks for PCP/toxo
immediately if MAC

25
how often is lencapavir given after first SC dose
every 6 months
26
which integrase inhibitor is approved as an intramuscular long-acting formulation
cabotegravir
27
for a treatment-naive PLWH to be prescribed abacavir, the HLA-B*5701 test must result as ____
negative
28
which NNRTI requires an acidic environment for absorption
rilpivirine
29
which integrase inhibitor is associated with a 0.1-0.4 mg/dL SCr increase due to inhibition of tubular secretion of creatinine
dolutegravir
30
what is the first-line initial therapy for a patient receiving long-acting cabotegravir for PrEP
DRV/c/FTC/TAF darunavir/cobicistat/emtricitabine/tenofovir alafenamide
31
which protease inhibitor requires an acidic environment for absorption
atazanavir
32
when is 2 drug therapy dolutegravir/lamivudine not indicated
HBV co-infection HIV RNA>500,000 copies