HIV

Question 1

capsid inhibitor

Answer 1

lencapavir

Question 2

gp120 inhibitors

Answer 2

fostemsavir
temsavir

Question 3

CCR5 antagonist

Answer 3

maraviroc

Question 4

NRTIs

Answer 4

lamivudine
emtricitabine
abacavir
tenofovir DF
tenofovir AF
zidovudine

Question 5

NNRTIs

Answer 5

doravirine
efavirenz
rilpivirine

Question 6

INSTIs

Answer 6

bictegravir
cabotegravir
dolutegravir
elvitegravir
raltegravir

Question 7

protease inhibitors

Answer 7

atazanavir
darunavir
ritonavir

Question 8

which drug requires tropism test

Answer 8

maraviroc

can use if CCR5-tropic disease

NOT if dual/mixed-tropic or CXCR4-tropic virus

Question 9

which drug requires HLA-B*5701 testing

Answer 9

abacavir

Question 10

which tenofovir causes renal, bone toxicity

Answer 10

DF

Question 11

which regimen has an optional 4-week oral lead in period

Answer 11

injectable CAB+ RPV

Question 12

laboratory testing parameters for HIV

Answer 12

HIV RNA: goal undetectable
CD4 count: goal >200 cells/mm3

Question 13

when to initiate prophylaxis against opportunistic infections

Answer 13

CD4 count < 200 cells/mm3

Question 14

when to initiate prophylaxis against PCP

Answer 14

CD4<200

Question 15

when to initiate prophylaxis against toxoplasma

Answer 15

CD4<100

Question 16

when to initiate prophylaxis against MAC

Answer 16

CD4<50 and not currently on ART

Question 17

vaccinations in PLWH

Answer 17

live attenuated influenza contraindicated
live replicating Mpox contraindicated

MMR and varicella contraindicated if CD4<200

Question 18

notable adverse effects of the integrase inhibitors

Answer 18

weight gain

Question 19

notable drug interactions for the integrase inhibitors

Answer 19

all: avoid or space out divalent cations (2h before or 6h after)

bictegravir: avoid rifampin

dolutegravir: max metformin dose is 500 bid

elvitegravir: no lovastatin or simvastatin. caution with steroids and contraceptives

Question 20

rilpivirine drug interactions

Answer 20

no PPIs
no dexamethasone

Question 21

protease inhibitor drug interactions

Answer 21

no lovastatin or simvastatin, max doses for other statins
caution with antiarrhythmics, contraceptives
avoid PPIs with atazanavir
caution with steroids: beclomethasone preferred

Question 22

PrEP options

Answer 22

TDF/FTC
TAF/FTC
LA CAB

Question 23

which PrEP treatment can cisgender women not get

Answer 23

TAF/FTC

Question 24

when opportunistic infection treatment is needed, when to start ART

Answer 24

within 2 weeks for PCP/toxo
immediately if MAC

Question 25

how often is lencapavir given after first SC dose

Answer 25

every 6 months

Question 26

which integrase inhibitor is approved as an intramuscular long-acting formulation

Answer 26

cabotegravir

Question 27

for a treatment-naive PLWH to be prescribed abacavir, the HLA-B*5701 test must result as ____

Answer 27

negative

Question 28

which NNRTI requires an acidic environment for absorption

Answer 28

rilpivirine

Question 29

which integrase inhibitor is associated with a 0.1-0.4 mg/dL SCr increase due to inhibition of tubular secretion of creatinine

Answer 29

dolutegravir

Question 30

what is the first-line initial therapy for a patient receiving long-acting cabotegravir for PrEP

Answer 30

DRV/c/FTC/TAF
darunavir/cobicistat/emtricitabine/tenofovir alafenamide

Question 31

which protease inhibitor requires an acidic environment for absorption

Answer 31

atazanavir

Question 32

when is 2 drug therapy dolutegravir/lamivudine not indicated

Answer 32

HBV co-infection
HIV RNA>500,000 copies