HIV Flashcards
Study
Name the ARVs that are NNRTIs
Efavirenz
Nevirapine
Entravirine
Rilpivitine
What is the major side effects of Sustiva ?
Nightmares , Rash , headache
What are the drug interaction with Sustiva
Decrease level of rifampin , rifabutin , Clarithromycin
What are the side effects of Nevirapine ?
Rash , Thrombocytopenia , hepatitis
Name the ARV and class that causes Redistribution of Fat .
Lopinavir 400mg bd
Atazanavir 300mg od
PIs
Which ARV cause HYPERBILIRUBIMIA can cause jaundice and HYPERGLYCEMIA
Atazanavir
Name the PI ARV and give there dosage .
Darunavir 600mg bd
Atazanavir 300mg od
Lopinavir 400mg bd
True or false all PI drugs are given with Ritanavir .
True
What drugs interacts with Atazanavir ?
H2 receptor blockers
PPI
What class of drug interacts with Lopinavir
CCB and warfarin
True or false RITANAVIR is a P450 Inhibitor
True
Name the different Integrase inhibitors and there daily dosage.
Doltegravir 50mg of HIV naive and 50 mg bd HIV experience
Raltegravir 400mg bd
What are the side effects of raltegravir
Rhandomyloysis
Cpk elevation
What are the side effects of Dolutegravir
Insomnia , fatigue
True or false Efavirenz should be taken on a full stomach
False
True or false
Oral contraceptive can be given with Nevirapine because it increases the effects of ethinyl estradiol
False .. Nevirapine decrease the effects of oral contraceptive because it’s a potent CYP50 3a4 inducer .
What are the side effects of Etravirine
Peripheral neuropathy and myopathy
Which hiv medication causes renal toxicity and bone meneral loss
Tenofovir
Which ARV increase the risk of neutropenia when given with BACTRIM and Granciclovir
Zidovudine
Which ARV causes severe Anaemia
Zidovudine
What are the major side effects of lamivudine
Hair loss, Pancreatitis in children and anemia
What are the side effects of abacavir ..
Hypersensitivity
What are the four stages of HIV infection
The window period
Seroconversion
Symptoms free
AIDS
Name a HIV entry inhibitor
Enfuvirtide
Name a CCR5 Antagonist
Maraviroc ( selzentry)
What are the integrase inhibitors and there dose
Raltegravir 400mg bd
Elvitegravir
Dolutegravir 50 mg od
what prophylaxis given when an HIV CD4 cell count <100 cells/mm3 . Name the drugs and dosage .
- Toxoplasma Gondii
DRUG :
TMP/SMX 1 D/S /DAY
or
Dapsone 50mg /day + Pyrimethamine 50 mg / week
- Mycobacterium Avium Complex
DRUG;
Azithromycin 1250 weekly
or Clarithromycin 500mg bd
What drug therapy use to treat Pneumocystis Pneumonia
Children ; Bactrim 15-20mg /kg / day / q6h *21 days
adults : Bactrim 2 DS tds * 21
OR
Clindamycin 600 - 900 mg Iv q6h * 21 day
300- 450 mg q6h * 21 days
what is the drug regime use to treat CANDIDAL INFECTION in HIV patients
Fluconazole 100mg od * 1 week.
what is the Drug regime for CANDIDAL OSEOPHAGITIS
Flucanazole 200 - 300 mg od *3 weeks
Treatment of HERPES Zoster
Acyclovir (ZOVIRAX) 800mg orally 5 times a day for 7 - 10 days
alteranative Valacyclovir (VALTREX) 1g po tid * 7- 10 days
herpes simple complex treatment
acyclovir 400 mg q8 h for 7- 10 days or Valacyclovir 1gm twice daily for 7-10 days .
MAC treatment
Clarithromycin 500mg twice daily/ Azithromycin 500mg po od + ethambutol 15mg /kg /day +/- Rifabutin 300 mg po od
What is Herpes zoster,
also known as shingles, is caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes varicella (chickenpox).
What is PCP treatment in children
Bactrim 15- 20 mg/ kg / day in divided dose 6 to 8 hours for 21 days
What is PCP Prophylaxis in children
5 to 10 mg TMP/ kg/ dose po od or every 12 hours 2-3 times a week on consecutive days or alternating days
PROPHYLAXIS OF PCP IN ADULT
1D/S tablet / day or 2 SS tablet / day
or
1D/S 3 times weekly until CD4 less than 350 cells / mm3 for more than 3 months
Eg
Bactrim 160 mg alt po * 6/12
Why can’t Bactrim given in children less than two months
SMX part of drug cause jaundice by increasing bilirubin which leads to neurotoxicity
Base in the 2020 guidline what is the first line treatment for HIV
Ten 300 mg lam 300mg dul 50 mg po od
I
What is the alternative drug for tenovovir
Entricitabine 200 mg po od (EMTRIVA)
How do you treat Preexposure Prophylaxis (PrEP)
• Truvada® (emtricitabine/tenofovir disoproxil fumarate) 1 t po od
Post – Exposure Prophylaxis (PEP) treatment
Ten lam dul for 28 days
Flucanazole
Diflucan
Valacyclovir
VALTREX
Dapsone
Aczone
pyrimethamine
Daraprim 25 mg tablet
Azithromycin
Zithromax
Ethambutol
Myambutol
Combivir
Zed/lam
TRIZIVIR
Abacavir / Lamivudine / Zidovudine
epzicom
Abacavir / Lamivudine
Truvada
Emtricitabine / Tenofovir
Nevirapine
Viramune
Efavirenz
Sustiva
Etravirine
Intelence
Ritonavir
Norvir
Atazanavir
Reyataz
Lopinavir/ritonavir
Kaletra
lamivudine
Epivir
abacavir
Ziagen
tenofovir DF*
Viread
zidovudine
Retrovir