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1
Q

Name the ARVs that are NNRTIs

A

Efavirenz
Nevirapine
Entravirine
Rilpivitine

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2
Q

What is the major side effects of Sustiva ?

A

Nightmares , Rash , headache

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3
Q

What are the drug interaction with Sustiva

A

Decrease level of rifampin , rifabutin , Clarithromycin

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4
Q

What are the side effects of Nevirapine ?

A

Rash , Thrombocytopenia , hepatitis

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5
Q

Name the ARV and class that causes Redistribution of Fat .

A

Lopinavir 400mg bd
Atazanavir 300mg od

PIs

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6
Q

Which ARV cause HYPERBILIRUBIMIA can cause jaundice and HYPERGLYCEMIA

A

Atazanavir

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7
Q

Name the PI ARV and give there dosage .

A

Darunavir 600mg bd

Atazanavir 300mg od

Lopinavir 400mg bd

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8
Q

True or false all PI drugs are given with Ritanavir .

A

True

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9
Q

What drugs interacts with Atazanavir ?

A

H2 receptor blockers

PPI

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10
Q

What class of drug interacts with Lopinavir

A

CCB and warfarin

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11
Q

True or false RITANAVIR is a P450 Inhibitor

A

True

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12
Q

Name the different Integrase inhibitors and there daily dosage.

A

Doltegravir 50mg of HIV naive and 50 mg bd HIV experience

Raltegravir 400mg bd

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13
Q

What are the side effects of raltegravir

A

Rhandomyloysis

Cpk elevation

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14
Q

What are the side effects of Dolutegravir

A

Insomnia , fatigue

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15
Q

True or false Efavirenz should be taken on a full stomach

A

False

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16
Q

True or false

Oral contraceptive can be given with Nevirapine because it increases the effects of ethinyl estradiol

A

False .. Nevirapine decrease the effects of oral contraceptive because it’s a potent CYP50 3a4 inducer .

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17
Q

What are the side effects of Etravirine

A

Peripheral neuropathy and myopathy

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18
Q

Which hiv medication causes renal toxicity and bone meneral loss

A

Tenofovir

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19
Q

Which ARV increase the risk of neutropenia when given with BACTRIM and Granciclovir

A

Zidovudine

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20
Q

Which ARV causes severe Anaemia

A

Zidovudine

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21
Q

What are the major side effects of lamivudine

A

Hair loss, Pancreatitis in children and anemia

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22
Q

What are the side effects of abacavir ..

A

Hypersensitivity

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23
Q

What are the four stages of HIV infection

A

The window period
Seroconversion
Symptoms free
AIDS

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24
Q

Name a HIV entry inhibitor

A

Enfuvirtide

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25
Name a CCR5 Antagonist
Maraviroc ( selzentry)
26
What are the integrase inhibitors and there dose
Raltegravir 400mg bd Elvitegravir Dolutegravir 50 mg od
27
what prophylaxis given when an HIV CD4 cell count <100 cells/mm3 . Name the drugs and dosage .
1. Toxoplasma Gondii DRUG : TMP/SMX 1 D/S /DAY or Dapsone 50mg /day + Pyrimethamine 50 mg / week 2. Mycobacterium Avium Complex DRUG; Azithromycin 1250 weekly or Clarithromycin 500mg bd
28
What drug therapy use to treat Pneumocystis Pneumonia
Children ; Bactrim 15-20mg /kg / day / q6h *21 days adults : Bactrim 2 DS tds * 21 OR Clindamycin 600 - 900 mg Iv q6h * 21 day 300- 450 mg q6h * 21 days
29
what is the drug regime use to treat CANDIDAL INFECTION in HIV patients
Fluconazole 100mg od * 1 week.
30
what is the Drug regime for CANDIDAL OSEOPHAGITIS
Flucanazole 200 - 300 mg od *3 weeks
31
Treatment of HERPES Zoster
Acyclovir (ZOVIRAX) 800mg orally 5 times a day for 7 - 10 days alteranative Valacyclovir (VALTREX) 1g po tid * 7- 10 days
32
herpes simple complex treatment
acyclovir 400 mg q8 h for 7- 10 days or Valacyclovir 1gm twice daily for 7-10 days .
33
MAC treatment
Clarithromycin 500mg twice daily/ Azithromycin 500mg po od + ethambutol 15mg /kg /day +/- Rifabutin 300 mg po od
34
What is Herpes zoster,
also known as shingles, is caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes varicella (chickenpox).
35
What is PCP treatment in children
Bactrim 15- 20 mg/ kg / day in divided dose 6 to 8 hours for 21 days
36
What is PCP Prophylaxis in children
5 to 10 mg TMP/ kg/ dose po od or every 12 hours 2-3 times a week on consecutive days or alternating days
37
PROPHYLAXIS OF PCP IN ADULT
1D/S tablet / day or 2 SS tablet / day or 1D/S 3 times weekly until CD4 less than 350 cells / mm3 for more than 3 months Eg Bactrim 160 mg alt po * 6/12
38
Why can’t Bactrim given in children less than two months
SMX part of drug cause jaundice by increasing bilirubin which leads to neurotoxicity
39
Base in the 2020 guidline what is the first line treatment for HIV
Ten 300 mg lam 300mg dul 50 mg po od
40
I
41
What is the alternative drug for tenovovir
Entricitabine 200 mg po od (EMTRIVA)
42
How do you treat Preexposure Prophylaxis (PrEP)
• Truvada® (emtricitabine/tenofovir disoproxil fumarate) 1 t po od
43
Post – Exposure Prophylaxis (PEP) treatment
Ten lam dul for 28 days
44
Flucanazole
Diflucan
45
Valacyclovir
VALTREX
46
Dapsone
Aczone
47
pyrimethamine
Daraprim 25 mg tablet
48
Azithromycin
Zithromax
49
Ethambutol
Myambutol
50
Combivir
Zed/lam
51
TRIZIVIR
Abacavir / Lamivudine / Zidovudine
52
epzicom
Abacavir / Lamivudine
53
Truvada
Emtricitabine / Tenofovir
54
Nevirapine
Viramune
55
Efavirenz
Sustiva
56
Etravirine
Intelence
57
Ritonavir
Norvir
58
Atazanavir
Reyataz
59
Lopinavir/ritonavir
Kaletra
60
lamivudine
Epivir
61
abacavir
Ziagen
62
tenofovir DF*
Viread
63
zidovudine
Retrovir

HIV (6 decks)

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