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HIV Flashcards

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1
Q

Name the ARVs that are NNRTIs

A

Efavirenz
Nevirapine
Entravirine
Rilpivitine

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2
Q

What is the major side effects of Sustiva ?

A

Nightmares , Rash , headache

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3
Q

What are the drug interaction with Sustiva

A

Decrease level of rifampin , rifabutin , Clarithromycin

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4
Q

What are the side effects of Nevirapine ?

A

Rash , Thrombocytopenia , hepatitis

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5
Q

Name the ARV and class that causes Redistribution of Fat .

A

Lopinavir 400mg bd
Atazanavir 300mg od

PIs

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6
Q

Which ARV cause HYPERBILIRUBIMIA can cause jaundice and HYPERGLYCEMIA

A

Atazanavir

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7
Q

Name the PI ARV and give there dosage .

A

Darunavir 600mg bd

Atazanavir 300mg od

Lopinavir 400mg bd

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8
Q

True or false all PI drugs are given with Ritanavir .

A

True

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9
Q

What drugs interacts with Atazanavir ?

A

H2 receptor blockers

PPI

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10
Q

What class of drug interacts with Lopinavir

A

CCB and warfarin

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11
Q

True or false RITANAVIR is a P450 Inhibitor

A

True

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12
Q

Name the different Integrase inhibitors and there daily dosage.

A

Doltegravir 50mg of HIV naive and 50 mg bd HIV experience

Raltegravir 400mg bd

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13
Q

What are the side effects of raltegravir

A

Rhandomyloysis

Cpk elevation

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14
Q

What are the side effects of Dolutegravir

A

Insomnia , fatigue

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15
Q

True or false Efavirenz should be taken on a full stomach

A

False

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16
Q

True or false

Oral contraceptive can be given with Nevirapine because it increases the effects of ethinyl estradiol

A

False .. Nevirapine decrease the effects of oral contraceptive because it’s a potent CYP50 3a4 inducer .

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17
Q

What are the side effects of Etravirine

A

Peripheral neuropathy and myopathy

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18
Q

Which hiv medication causes renal toxicity and bone meneral loss

A

Tenofovir

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19
Q

Which ARV increase the risk of neutropenia when given with BACTRIM and Granciclovir

A

Zidovudine

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20
Q

Which ARV causes severe Anaemia

A

Zidovudine

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21
Q

What are the major side effects of lamivudine

A

Hair loss, Pancreatitis in children and anemia

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22
Q

What are the side effects of abacavir ..

A

Hypersensitivity

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23
Q

What are the four stages of HIV infection

A

The window period
Seroconversion
Symptoms free
AIDS

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24
Q

Name a HIV entry inhibitor

A

Enfuvirtide

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25
Q

Name a CCR5 Antagonist

A

Maraviroc ( selzentry)

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26
Q

What are the integrase inhibitors and there dose

A

Raltegravir 400mg bd
Elvitegravir
Dolutegravir 50 mg od

27
Q

what prophylaxis given when an HIV CD4 cell count <100 cells/mm3 . Name the drugs and dosage .

A
  1. Toxoplasma Gondii

DRUG :
TMP/SMX 1 D/S /DAY
or
Dapsone 50mg /day + Pyrimethamine 50 mg / week

  1. Mycobacterium Avium Complex

DRUG;
Azithromycin 1250 weekly
or Clarithromycin 500mg bd

28
Q

What drug therapy use to treat Pneumocystis Pneumonia

A

Children ; Bactrim 15-20mg /kg / day / q6h *21 days

adults : Bactrim 2 DS tds * 21

OR

Clindamycin 600 - 900 mg Iv q6h * 21 day
300- 450 mg q6h * 21 days

29
Q

what is the drug regime use to treat CANDIDAL INFECTION in HIV patients

A

Fluconazole 100mg od * 1 week.

30
Q

what is the Drug regime for CANDIDAL OSEOPHAGITIS

A

Flucanazole 200 - 300 mg od *3 weeks

31
Q

Treatment of HERPES Zoster

A

Acyclovir (ZOVIRAX) 800mg orally 5 times a day for 7 - 10 days

alteranative Valacyclovir (VALTREX) 1g po tid * 7- 10 days

32
Q

herpes simple complex treatment

A

acyclovir 400 mg q8 h for 7- 10 days or Valacyclovir 1gm twice daily for 7-10 days .

33
Q

MAC treatment

A

Clarithromycin 500mg twice daily/ Azithromycin 500mg po od + ethambutol 15mg /kg /day +/- Rifabutin 300 mg po od

34
Q

What is Herpes zoster,

A

also known as shingles, is caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes varicella (chickenpox).

35
Q

What is PCP treatment in children

A

Bactrim 15- 20 mg/ kg / day in divided dose 6 to 8 hours for 21 days

36
Q

What is PCP Prophylaxis in children

A

5 to 10 mg TMP/ kg/ dose po od or every 12 hours 2-3 times a week on consecutive days or alternating days

37
Q

PROPHYLAXIS OF PCP IN ADULT

A

1D/S tablet / day or 2 SS tablet / day

or

1D/S 3 times weekly until CD4 less than 350 cells / mm3 for more than 3 months

Eg

Bactrim 160 mg alt po * 6/12

38
Q

Why can’t Bactrim given in children less than two months

A

SMX part of drug cause jaundice by increasing bilirubin which leads to neurotoxicity

39
Q

Base in the 2020 guidline what is the first line treatment for HIV

A

Ten 300 mg lam 300mg dul 50 mg po od

40
Q

I

A
41
Q

What is the alternative drug for tenovovir

A

Entricitabine 200 mg po od (EMTRIVA)

42
Q

How do you treat Preexposure Prophylaxis (PrEP)

A

• Truvada® (emtricitabine/tenofovir disoproxil fumarate) 1 t po od

43
Q

Post – Exposure Prophylaxis (PEP) treatment

A

Ten lam dul for 28 days

44
Q

Flucanazole

A

Diflucan

45
Q

Valacyclovir

A

VALTREX

46
Q

Dapsone

A

Aczone

47
Q

pyrimethamine

A

Daraprim 25 mg tablet

48
Q

Azithromycin

A

Zithromax

49
Q

Ethambutol

A

Myambutol

50
Q

Combivir

A

Zed/lam

51
Q

TRIZIVIR

A

Abacavir / Lamivudine / Zidovudine

52
Q

epzicom

A

Abacavir / Lamivudine

53
Q

Truvada

A

Emtricitabine / Tenofovir

54
Q

Nevirapine

A

Viramune

55
Q

Efavirenz

A

Sustiva

56
Q

Etravirine

A

Intelence

57
Q

Ritonavir

A

Norvir

58
Q

Atazanavir

A

Reyataz

59
Q

Lopinavir/ritonavir

A

Kaletra

60
Q

lamivudine

A

Epivir

61
Q

abacavir

A

Ziagen

62
Q

tenofovir DF*

A

Viread

63
Q

zidovudine

A

Retrovir

HIV (6 decks)

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