HIV Flashcards
NNRTI Drugs
Non-nucleoside reverse transcriptase inhibitors
ART
antiretroviral therapy
IRIS
Immube reconstitution Syndrome
PI Drugs
Protease inhibitors
INI Driugs
Integrase inhibitors (a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell)
Algorithm before starting HIV treatment
Investigations: HIV testing HLA B*5701 status CD4 count HIV 1/2 Viral load History: Check drug history Check medical history Renal/Hepatic function Pregnancy Partner Children Examinations: Blood pressure, STI
Difference between HIV 1 and 2
HIV 1 Is more infectiouas (95% of cases)
HIV 2 is relatively less infectious, progresses slower and lower fatality rate
Tenofovir function
Prevents metabolism of other drugs to increase half life
Retrovirus
A retrovirus is a type of virus that inserts a copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell.
Monitoring ART (1st 6 months)
History (adherence/ tolerability) [2-4 weeks then every visit]
Viral load
Investigations (Renal/Hepatic function etc) [2-4 weeks, 3 months, 6 months]
Side effects
When to change treatment
Increase CD4 Increase/no change in viral load Adherence Side effects Resistance
What might constitute good adherence?
Right time
Dose
Food at correct time (If necessary)
What might constitute good adherence?
Right time
Dose
Food at correct time (If necessary)
What can affect adherence?
Mental health Tablet burden Support system Education Side effect concerns Supply
