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NAPLEX 2021 (select RxPrep&PNN) > HIV > Flashcards

HIV Flashcards

1
Q

HIV drugs that work in stage 1 : binding/attachment

A

maraviroc (Selzentry)

ibalizumab-uiyk (Trogarzo)

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2
Q

HIV drugs that working in stage 2: fusion

A

enfuvirtide (Fuzeon)

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3
Q

HIV drugs that working in stage 3: reverse transcription

A

NNRT

NRTI

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4
Q

HIV drugs that working in stage 4: integration

A

INSTi

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5
Q

HIV drugs that working in stage 7: budding and maturation

A

protease inhibitors

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6
Q

HIV agents one-pill, once-daily

A

Biktarvy
Triumeq
Dovato

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7
Q

Biktarvy

A

bictegravir
emtricitabine
TAF

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8
Q

Triumeq

A

dolutegravir
abacavir
lamivudine

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9
Q

Dovato

A

dolutegravir

lamivudine

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10
Q

Truvada

A

emtricitabine

TDF

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11
Q

Descovy

A

emtricitabine

TAF

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12
Q

Tivicay

A

dolutegravir

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13
Q

Isentress

A

raltegravir

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14
Q

PrEP agents

A

Truvada

Descovy

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15
Q

PEP agent

A

Truvada

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16
Q

Stribild

A

elvitegravir
cobicistat
emtricitabine
TDF

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17
Q

Genvoya

A

elvitegravir
cobicistat
emtricitabine
TAF

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18
Q

Atripla

A

efavirenez
emtricitabine
TDF

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19
Q

Odefsey

A

emtricitabine
rilpivrine
TAF

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20
Q

Symfi

A

efavirenz
lamivudine
TDF

21
Q

Epzicom

A

abacavir

lamivudine

22
Q

NRTi

A

tenofovir disoproxil fumarate

tenofovir alafenamide

lamivudine

emtricitabine

abacavir

zidovudine

didanosine

stavudine

23
Q

integrase strand transfer inhibitors (INSTIs)

A

-end in tegravir

bictegravir

elvitegravir

dolutegravir

raltegravir

24
Q

Protease inhibitors

A
  • end in -nevir

atazanvir

darunavir

fosamprenavir

indinavir

lopinavir + ritonavir

saquinavir

tipranavir

25
Q

enhancers

A

ritonavir

cobicistat

26
Q

NRTi that does NOT need renal dose adjustment

A

Abacavi

27
Q

NRTi used in labor and delivery when mother’s viral load is >1000 copies/ml

A

IV Zidovudine

28
Q

NRTI BOXED warning

A

lactic acidosis

severe hepatomegaly with steatosis

29
Q

NRTi NOT used to treat both HIV/HBV

A

abacavir

30
Q

Allele screening for abacavir

A

HLA-B*5701

31
Q

Warning and side effect for zidovudine

A

myopathy

neutropenia

anemia

32
Q

NRTI that have a warning for lipodystrophy

A

stavudine

didanosine

zidovudine

33
Q

Side effects for all NRTI

A

nausea

diarrhea

34
Q

Warning for TDF/AF

A

Nephrotoxicity

Osteoporosis

Fanconi Syndrome

35
Q

Cations that cannot be taken at the same time as INSTI

A

Aluminum

Magnesium

36
Q

NNRTi

A

efavirenz

rilpivirine

doravirine

nevirapine

etravirine

delavidine

37
Q

Rilpivirine and food

A

must be taken with a full meal; no protein drink subsitution

38
Q

Efavirenz and food

A

take on a empty stomach at bedtime

39
Q

Boxed warning for all NNRTi

A

hepatotoxicity with severe rash

40
Q

Contraindication for rilpivirine

A

use with PPI (drug absorption is acid-dependent)

41
Q

Warning/side effect for rilpivirine

A

depression

insomnia

QT prolongation

42
Q

PI taken without food

A

fosamprevair oral solution

43
Q

Do NOT take Kaletra and ritonavir with __ __ or __

A

metronidazole

tinidazole

disulfram

44
Q

PI caution with sulfa allergy

A

darunavir

fosamprenavir

tipranavir

45
Q

fosamprenvir may cause ___ in patient’s with a sulfa allergy

A

hemolytic anemia

46
Q

CrCl cutoff for Stribild

A

<50; do not use

47
Q

CrCl cut off for Genvoya

A

<30; do not use

48
Q

Maraviroc only works with __ ___ disease.

A

CCR-5 tropic

NAPLEX 2021 (select RxPrep&PNN) (5 decks)

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