History of the water pore

Question 1

What sis cyro-electon microscopy work of AQP1 show?

Answer 1

It is a TETRAMER

With a crystallised structure

Question 2

How many water pores does AQP1 potentially have?

Answer 2

4 (one in each of the monomeric units)

Possibly 1 large pore in the centre

Question 3

How can we prove that water goes through AQP1 through the 4 monomeric pores rather than the central pore?

Answer 3

Using TANDEM DIMERS of AQP1