History Of Microbiology Flashcards

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1
Q

4 stages/Era of history of microbiology

A

1st the era of speculation from 5000 Bc – 1675
2nd, the era of observation from 1675 – mid –
19th C.
3rd, the era of cultivation from mid – 19th C - beginning of 20th C
4th the era of philosophical study from early 2oth C – Now

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2
Q

Infection is about ……. Of pre and post hospital admission.

A

Infection is about 70% of pre and post hospital admission.

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3
Q

Hx of Microbiology is:
Founded upon two pillars of ……. and ……..

A

Hx of Microbiology is:
Founded upon two pillars of craft and philosophy

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4
Q

First was the craft of food ……….and ………

A

First was the craft of food preservation and fermentation

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5
Q

In the era of speculation, Cicero opined that…………

A

In the era of speculation, Cicero opined that fevers, were caused by the multiplication of minute animals;

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6
Q

Fracastorius wrote of……

A

then came fracastorius who wrote of “contagium vivum”

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7
Q

Infection is about…….of pre and post hospital admission. Hx of Microbiology is:

A

Infection is about 70% of pre and post hospital admission. Hx of Microbiology is:

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8
Q

In the era of observation 1675 Anthony van Leeuwenhoek

A

Published his work in animalcules (bacteria)

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9
Q

Louis Pasteur (1822-1895)

A

Worked on fermentation, cultivation in liquid media, sterilization, attenuated vaccines for anthrax and rabies.

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10
Q

Paul ehrlich, Elie matchnikoff and dfeiffer

A

Chemotherapeutic compounds like trypan red

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11
Q

Paul ehrlich

A

Salvarsan- used to treat syphilis and trypanosomiasis

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12
Q

In 1935 Domagk discovered…….

A

In 1935 Domagk discovered prontosil Red, which was non-toxic to mammals but killed streptococci, Neisseria and other bacteria.

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13
Q

In 1928 Alexander Fleming discovered

A

In 1928 Alexander Fleming discovered penicillin from Penicillium notatum.

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14
Q

In 1939, sir, Howard Florey at Oxford…..

A

In 1939, sir, Howard Florey at Oxford, extracted and purified Penicillin from its fungus.

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15
Q

Robert Koch (1843 – 1910)

A

􏰀 Use of 1st solid media
􏰀 1st described bacterial endospores in anthrax
􏰀 Stained tubercle bacilli with alkaline methylene
blue
􏰀 Originated the Koch’s postulates.
􏰀 The germ theory of disease

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16
Q

Louis Pasteur (1822 – 1895)

A

Pasteurization (sterilization).
􏰀 Fermentation
􏰀 Barterial culture in liquid media
􏰀 Attenuated vaccines from anthrax, rabies and fowl cholera (Pasteurella septica).

17
Q

1882 – Ziehl introduced…..

A

1882 – Ziehl introduced phenol in place of aniline water for staining tubernacle bacilli

18
Q

1883 – Neelsen described his modification of ziehls method by…..

A

1883 – Neelsen described his modification of Ziehl’s method by introducing hot carbol fuchsin and 15% H2S04 as decolorizing agent.

19
Q

1884 – Danish Pathologist, Hans Christian Gram……

A

1884 – Danish Pathologist, Hans Christian Gram – introduced the technique of counter-staining after decolorization (This is the birth of G+ and G- bacteria)

20
Q

1900 – MacConkey……

A

1900 – MacConkey – described the 1st solid differential medium.

21
Q

1916 – McIntosh and Fildes……

A

1916 – McIntosh and Fildes – invented the McIntosh & Fildes Anaerobic Jar

22
Q

Frederick Griffith (1879 – 1941) and O.T. Avery (1877 – 1953) discovered….

A

Frederick Griffith (1879 – 1941) and O.T. Avery (1877 – 1953) discovered Transformation in bacteria.

23
Q

1947 – Tatum and Joshua Lederberg discovered Conjugation…..

A

1947 – Tatum and Joshua Lederberg discovered Conjugation; they coined the terms fertility Plus
(F+) for donor cells and fertility minus (F-) for receptor cells.

24
Q

1961 – Prof. T. Watanabe…..

A

1961 – Prof. T. Watanabe – Elucidated the phenomenon of the “infectious drug resistance”

25
Q

Edward Jenner (1749-1823)

A

Edward Jenner (1749-1823) Cowpox vaccination

26
Q

􏰀 Von Behring and Kitasato (1854-1917)

A

􏰀 Von Behring and Kitasato (1854-1917) –they invented induced active and passive immunity and coined the term anti-toxin.

27
Q

Karl Landsteiner (1868 – 1943)

A

Karl Landsteiner (1868 – 1943) he established the existence of the four ABO blood groups.

28
Q

In 1911, kharl landsteiner…..

A

In 1911, he showed that antibody activity was associated with the globulin fraction of the serum