History of Medicine Flashcards

1
Q

What has decreased the early signs of diseases ?

A

Clean water and sanitations have decreased the incidence of most infectious diseases and death rates.

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2
Q

What are Ancient Civilizations : Egyptian Medicine

A

Between the 4000 and 1000 BC

had many remedies for illness: spells, incantations and magic. Illness and death: actions of the gods and demonic possession. -

-Despite that, some of the treatments were effective and still used today. -They treated disease based on what was perceived as the cause, a principle used today

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3
Q

Who were the first to treat infectious diseases ?

A

It was Egyptians were the first to treat diseases systematically.

They recognized that weather and ingestion of noxious substances affected the body •

They used drugs: castor or olive oil, opium, saffron. • Pulse and body temperature were measured. Diet and cleanliness were prescribed. •

Heart was considered a vital organ, and respiration the most important function. •

Severe penalties for letting a patient die. Compound fracture was considered a fatal condition. •

Physicians specialized: eye, head, intestines, etc.

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4
Q

What also contributed to Ancient Cilvillation ?

A

Chinese’s Medicine

  • Chinese medicine also contributed to remedies used today.
  • An early Chinese emperor identified over 100 herbal remedies and invented acupuncture.
  • Magic and superstition was also part of Chinese medicine.
  • However, they discovered the use of iron to treat anaemia or opium as a narcotic to reduce pain.

Traditional Chinese herb therapies are evaluated today for the development of new therapeutic strategies.

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5
Q

What is Ancient Cilvialltion :Biblical Times consist of ?

A

-Disease was thought of as coming from gods. Treatments were used without any understanding as to why they worked. -

Basic notions about preventative medicine and the transmission of infectious diseases can be found in the Bible: relationship between rats and the plague or the segregation of the lepers

The Mosaic law also prescribed fumigation, decontamination of buildings, protection of water supplies, disposal of wastes, protection of food and sanitation of campsites.

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6
Q

What were the Greece Hippocrates interested in ?

A

Hippocrates was interested in determining the cause and treatment of disease.

Hippocrates believed in the healing power of nature, he prescribed diets, rest, fresh air, etc. He separated medicine from religion.

-His approach to disease and clinical observation were the basis of the prevention and control of infectious diseases.

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7
Q

What did the Greece Hippocrates specifically believe in ?

A

However, he believed in maintaining the balance of 4 types of humours or fluids: blood, phlegm, yellow bile and black bile.

However, he believed in maintaining the balance of 4 types of humours or fluids: blood, phlegm, yellow bile and black bile.

Disease was induced when these fluids were not in balance.

Bloodletting was based on this theory and persisted well into the early 19th century.

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8
Q

What did Rome do in terms of Public health and what did they adopt ?

A

Romans adopted from Greeks the search for scientific knowledge and public health measures:

Aqueducts were built to supply cities with clean water •

Sewers prevented spread of infectious diseases •

Street cleaning was required •

Public baths were available everywhere

• Physicians were educated at public expense, and their services were available to the poor

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9
Q

Who contributed in Rome :Public Health ?

A

Marcus Terentius Varro (116-217 BC) described “small creatures, invisible to the eye” that filled the air, were breathed in, and caused dangerous diseases.

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10
Q

What happened when the roman empire collapsed ?

A

The collapse of the centralized Roman government led to the downfall of aqueducts and sewer systems, which influenced the spread of disease.

The rise of new religions also affected the search for new scientific knowledge > early Christians reacted against the GrecoRoman emphasis on physical health and beauty.
The

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11
Q

The rise of the Islamic Empire ?

A

Muslim scholars collected, translated and supplemented classical Greek works as well as texts from India and Northern Africa.

Among the most prolific and influential scholars of this period are Al-Razi (e.g. father of paediatrics) and Ibn Sina (first medical encyclopaedia).

These texts were archived at the House of Wisdom in Baghdad and other centres of study.
Emerging from the early medieval period, Europe remained ignorant of much of this knowledge.

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12
Q

After the collapse of the Roman Empire ?(Middle Ages)

A

Pilgrimages helped in the transmission of infectious diseases like cholera.

Christian reaction to Islam, the Crusades, contributed to the spreading of cholera and leprosy.

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13
Q

What occurred as a result of the collapse of the Roman Empire ?

A

The most deadly of all pandemics were the waves of disease caused by bubonic plague: the “Black Death”

20% of Europe’s population perished from a combination of the plague and pulmonary anthrax. .

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14
Q

What occurred in the Middle ages as a result collapse of the roman empire ?

A

Syphilis spread rapidly through Europe shortly after the return of Columbus from America.

Other diseases known to exist during this period include: typhoid, typhus, diphtheria, streptococcal infections, and dysenteries. Isolation and quarantine were the only control methods, but they were practiced unevenly.

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15
Q

What also happened after the Roman empire ?

A

The Renaissance intellectual revolution stimulated scientific enquiry in all areas of human knowledge. -Leonardo da Vinci and Andreas Vesalius dissected the human body and founded the modern anatomy.

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16
Q

Renaissance:between the 14th and 17th centuries and marking the transition from the middle ages to modernity.

A

Girolamo Fracastoro recognized the infectious nature of syphilis, typhus and tuberculosis.

His work, De contagione, displaced the humoral doctrine of Hippocrates: there are specific causes for specific diseases.

17
Q

What was used during the Rennaissance in the late 16th and 17 th century ?(Enlightment)

A

In the late 16th and early 17th century the microscope was used for the first time in scientific investigations, by Galileo among others.

18
Q

What happened in the 17 th century after the collapse of the Roman Empire ?*(Enlinghtment)

A

-Quick development of the scientific method stimulated by inductive reasoning (Francis Bacon) and questioning of any former “truths” (Rene Descartes). -William

Harvey demonstrated the circulation of blood.

  • Anton van Leeuwenhoek described red blood cells and bacteria.
  • Athanasius Kircher linked the live microorganisms in the blood with disease.
19
Q

What occurred in 17 th century also? Enlinghtment)

A
  • Vitamin deficiency diseases like rickets (Vit. D) or beriberi (Vit. B1) were described.
  • Thomas Sydenham: treatment against malaria (quininebased) and invention of laudanum (liquid opium).
20
Q

Who discovered vaccine in the 18 th century ?Enlinghtment)

A

-During this century the scientists began to identify the organisms and causes for most diseases.

  • Edward Jenner overhead a dairymaid that she could not catch smallpox because she had already had cowpox. -
  • Jenner vaccinated a small boy with pus from a cowpox lesion, and after eight weeks inoculated him with smallpox.

The boy did not developed any symptoms of the disease. -Jenner’s findings was the beginning of a cascade of scientific breakthroughs in the 19th century.

21
Q

What occurred during the 19 th century ?Enlinghtment)

A

Louis Pasteur, first to demonstrate that microorganisms could be pathogenic to humans.

He developed pasteurization and vaccination against anthrax and rabies.

Based on Pasteur’s work, Joseph Lister applied antiseptics to surgical wounds > surgery 100 times safer.

22
Q

What also occurred in the 19 th century ?Enlinghtment)

A

Robert Koch, developed four postulates to identify an organism as the causative agent of a disease (germ theory):

1) it must always be present in the disease,
2) be capable of growth in pure culture in the laboratory,
3) cause the disease when injected in to a susceptible healthy animal,
4) be recovered from the experimental animal. He discovered the bacteria causing anthrax, cholera and tuberculosis.

23
Q

What did Ronald Ross discover in the 19 th century ?Enlinghtment)

A

Ronald Ross discovered the protozoan malarial parasite in human blood and his carrier, the anopheles mosquito > malaria could be controlled by destroying the mosquito larvae.

24
Q

What did Claude Bernard also discover in the 19 th century ?Enlinghtment)

A

Claude Bernard formulated the basic principles of research and experiment.
He discovered glycogen and its production by the liver.
He was the first to define milieu interieur, now known as homeostasis.

25
Q

What were other disciveres which occurred in the 19 th century ?Enlinghtment)

A

Roentgen discovered the X-ray and Marie and Pierre Curie discovered radium, useful for diagnosing and treating cancer, among other diseases.
Marie

26
Q

What occurred in the 20 th century ? Wonder Drugs

A

Vitamins were discovered in 1912 by Casimir Funk, and their isolation and synthesis allowed the cure of vitamin-deficiency diseases.

27
Q

Who discovered Antibiotics ? 20 century

A
  • Paul Elrich, first to use a specific chemical against a specific pathogen: arsphenamine against syphilis (1907).
  • Alexander Fleming discovers penicillin in 1928. Not purified in an effective and stable form until 1940.
  • Gerhard Domagk discovers sulfonamides (1935), the first ever commercially available antimicrobial drugs.
  • In 1943 Streptomycin was isolated by Albert Schatz, and helped in the cure of tuberculosis. Soon joined by isoniazid and para-aminosalicylic acid. First cooperative research works.
28
Q

What also occurred in the 20th century ?

A

Viruses could be finally seen and studied since 1930 and the discovery of the electron microscope.

In 1955, Jonas Salk introduce a killedvirus vaccine for poliomyelitis.

The inventor of the polio vaccine didn’t patent it:
“There is no patent. Could you patent the sun?”

29
Q

What are the Changing Patterns In the 20 th century ?

A
  • By 1930 deaths from non-infectious diseases had surpassed those from infectious diseases in the US and other developed countries.
  • People lived longer without infectious diseases.
  • No attention was required before to prevent or control heart diseases or cancer, which required longer life spans to emerge.
  • Lifestyle changes also contributed: stress, eating and drinking excesses, decrease in exercise, etc.
30
Q

What are the Changing Pattenrs in the 20th Century ?

A

Rapid development of medicine during 20th & 21st centuries.

  • From the production of insulin to control of diabetes, transplants, laser surgery, or new diagnostic tools (CAT, MRI or PET)…
  • To biomedicine: human genome sequencing, stem cells, personalized medicine…
31
Q

What are the Changing Patterns in the 20 Century ?

A

However, new emerging, re-emerging and drug-resistant infections have appeared all over the world.

Every day new strains are selected with mutations that make ineffective currently used vaccines, antimicrobials or antivirals. Misuse or abuse of antibiotics increase the apparition of resistances.

32
Q

What are the estimate burdens of Antibacterial Resistance?

A

European Union :500m population
Deaths;25,000 per year
Extra Pay:2.5 M extra hospital days

Thailand:
70m
Deaths:38,000 deaths
Hospital days :3.2m Hospital days

United states:
Population :300 M
23,000 deaths
2.0M ilnessees

33
Q

What can we do ?

A
  1. Know what were treating , improve diagnostic tests to detect infections within an hour weather its bacteria so it can help reduce antibiotic prescriptions .
  2. Change Farmers Practices , reduce intensive farming to eliminate the spread of diseases and infections .

Health experts say antiobitcs shouldn be used for animal growth

3 .Use viruses:
Phage Therpay uses viruses called bacteriphogaes to infect and kill bacteria .

This shows promises in Russia but not In west .

  1. Create new drugs
    - Antibiotcs are expensive to develop

5 .Other things
In addition we could:
-Develop vaccines (if possible…) -Control the environment (hand hygiene, smart surfaces, etc.)

-Better understanding of host-pathogen interactions