Histopath

Question 1

• understand the concept of chronic liver as the result of persistent liver inflammation and hepatocyte death, culminating in cirrhosis

Answer 1

v

Question 2

• list the main categories of chronic liver disease

Answer 2

LO- chronic hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, chronic biliary disorders and metabolic conditions

Question 3

• define chronic hepatitis and describe the hallmark feature of portal and periportal inflammation (interface hepatitis)

Answer 3

v

Question 4

• list the common causes of chronic hepatitis

Answer 4

v

Question 5

• define macrovesicular steatosis, and understand the distinction from steatohepatitis in terms of hepatocellular injury
list the common causes of steatosis and steatohepatitis - alcohol versus causes of non-alcoholic steatosis/steatohepatitis

Answer 5

v

Question 6

What cells are responsible for the collagen deposited with fibrosis of the liver?
What 2 features do they acquire?

Answer 6

Undergo a phenotype switch
Become stellate/more like myofibroblasts
(contractile and produce collagen)
Collagen becomes deposited in the space of Disse
Take home msg from the slide: source of collagen= activated hepatic stellate cells

Question 7

ALD: histology

Answer 7

• Fatty change – abnormal accumulation of lipid in hepatocytes (reversible and does not cause hepatocellular death or fibrosis)
• Alcoholic steatohepatitis (leads to hepatocellular death and fibrosis)
• Progressive fibrosis leading eventually to cirrhosis

Question 8

Steatosis versus Steatohepatitis

Answer 8

Steatosis is JUST fat vs
• Steatohepatitis is defined by the presence of fat + hepatocellular injury
• Hepatocellular injury is characterised by ballooning (swelling) and formation of Mallory-Denk bodies.