histone modifications

Question 1

what is genomic imprinting?

Answer 1

only one working copy of a gene is inherited and the other copy is epigenetically silenced

Question 2

how do diseases involving genomic imprinted genes occur?

Answer 2

segment containing the gene is deleted + the other copy is silenced -> important genes not expressed -> no active copies of the gene

Question 3

what is dosage compensation?

Answer 3

process that balances expression of sex-linked genes to offset the difference in sex-chromosome number

Question 4

what is X-chromosome inactivation?

Answer 4

one of the two x chromosomes is randomly and permanently inactivated in cells other than egg cells
ensures only one functional copy of x chr, like in males

Question 5

what is ChIP-seq?

Answer 5

chromatin immunoprecipitation sequencing:
some DNAs have protein bound to it. specific antibodies bind to the protein and is immunoprecipitated. bound DNA is coprecipitated, purified and sequenced

identifies genome-wide DNA binding sites for transcription factors and other proteins