Histology Pictures

Question 1

What is This?

Answer 1

Placental Site Trophoblastic Tumor

Monorphic cells arising from intermediate trophoblasts with poor ddx, propensity to invade myometrium.

Weak HCG expression because they lack extensive syncytiotrophoblastic tissue.

Question 2

What is this?

Answer 2

Placental Site Trophoblastic Tumor

Monorphic cells arising from intermediate trophoblasts with poor ddx, propensity to invade myometrium.

Weak HCG expression because they lack extensive syncytiotrophoblastic tissue.

Question 3

Placental Site Trophoblastic Tumor

Answer 3

Path: Weak hcg expresion, lack extensive syncytiotrophoblastic tissue; may secrete HPL

Px: 1/3 bleeding, 1/3 amenorrhea

Tx: Hysterectomy. Ovaries may be retained if nl. Lymphadenectomy controversial. Adjuvant chemo may be necessary