Hereditary Cancers Flashcards
1
Q
BRCA1
A
Breast Cancer 57%
2
Q
If family positive for BRCA
A
Test for specific variant
3
Q
If pt + BRCA
A
Genetic counseling to others
Monthly self-breast exam at 18
CBE twice yearly, annual mammo and MRI at 25
CA 125 and TVUS annually
4
Q
Risk reduction in BRCA
A
Chemopreventive (tamoxifen - decrease by 62%)
OCPs (60% decr of ov CA by 60^)
Ppx Mastectomy (90% decrease breast ca risk)
Ppx BSO (decr OV CA by 96%, Breast by 50%)
