Histology Of The Menstrual Cycle Flashcards
What are the two cycles of the menstrual cycle?
Ovarian cycle: several ovarian follicles, each housing a primary oocyte; undergo folliculogenesis in preparation for ovulation
Uterine cycle: endometrium prepares for implantation; if fertilization does not occur, endometrium is shed and menstruation occurs
What is the fx of the oviduct?
Catch ovulated secondary oocyte
Nourish oocyte and sperm
Provide fertilization microenvironment
Transport embryo to uterus
What are the regions of the oviduct?
What lines the ampulla and isthmus?
Proximal infundibulum with fimbriae
Long and thin-walled ampulla
Short and thick-walled isthmus
Intramural portion opens into uterus
Mucosal folds that project into the lumen
Describe the wall of the oviduct:
Mucosal layer? What does an increase and decrease in estrogen cause?
Simple columnar epithelium, lamina propria (loose CT with few smooth m cells)
Ciliated cells: enlarge, grow in height and produce cilia during folliculogenesis (increase estrogen); lose cilia and decrease in height during luteolysis (increase progesterone)
Nonciliated secretory cells (peg cells): secrete nutrients for the egg during migration (increase estrogen)
Describe the smooth muscle layer and serous a layer in the wall of the oviduct
What is the fx of peristaltic contractions and ciliary activity of epithelial cells?
Inner circular-spiral layer and outer longitudinal layer
Serous layer with large blood vessels
Propel oocyte/zygote towards uterus
Describe the layers of the endometrium of the uterus
What layer is lost during menstruation?
Epithelium: simple columnar with simple tubular endometrial glands
Functional layer: lost during menstruation; supplied by spiral arteries
Basal layer: retained during menstruation
Describe the myometrium of the uterus
Poorly defined smooth m
Central, circular layer; thick with blood vessels -> stratum vasculare
Outer and inner layers contain longitudinally or obliquely arranged fibers
Describe the perimetrium of the uterus
Serous covering posterior surface and part of anterior surface (remainder is adventitia)
What vasculature supplies the endometrium?
Before menstruation, contraction of the artery occurs at ____ junction.
What does this cause?
Arcuate arteries: straight segment supplies basal layer; coiled segment supplies functional layer and stretches with endometrial growth
Straight-coiled
Reduction in blood flow -> destruction of functional layer
What are the four phases of the menstrual cycle?
Proliferative phase
Secretory phase
Ischemic phase
Menstrual phase
Describe the proliferative phase of the menstrual cycle
Day 5-14 (just finished menses, endometrium thinnest)
Glands proliferate and cover surface
Spiral arteries elongated and become convoluted; extend from basal into functional layer
Estrogen dependent
Functional layer is thin, stroma is cellular, glands straight narrow empty
Describe the secretory phase of the menstrual cycle
Day 15-28 (ovulation)
Glands are convoluted (saw tooth)
Endometrium reaches maximum thickness
Spiral arteries continue to grow and extend into functional layer
Considerable leukocyte infiltration
Estrogen and progesterone
Functional layer less cellular, thicker than basal layer, tubular glands have saw tooth shape
Describe the ischemic phase of the menstrual cycle
1 day
Regression of corpus luteum
Reduction in blood supply causing intermittent ischemia
Necrosis of functional layer
Swelling/breakdown of glands
Stroma of functional layer is sponge like; breakdown of stromal matrix
Reduction in progesterone -> periodic constrictions of spiral A -> deprive O2 supply to the functional layer -> breakdown in spiral A floods lamina propria with blood -> functional layer detaches and sheds -> basal layer not affected because basal straight A supply blood
Describe the menstrual phase of the menstrual cycle
1-4 days
Stratum functionalis has sloughed away
Numerous RBCs and leukocytes
Stratum basalis remains intact
What are decidual cells?
What are the functions of decidual cells?
What is the decidual reaction?
During pregnancy, fibroblasts become decidual cells in lamina propria of the uterus; increase in size, store lipids and glycogen
Due to increase in progesterone
Maintains corpus leuteum
Provides nutrients to embryo
Modulates trophoblast invasion
Prevent immunologic rejection
Decidual reaction: functional layer will be shed as the decidua at parturition