HIstology/neural tracts

Question 1

Papp lantos bodies

Answer 1

Seen in multisystem atrophy- Glial cytoplasmic inclusion in the CNS

Question 2

Pick bodies

Answer 2

Seen in frototemporal dementia- Large dark staining aggregates of proteins in neural tissue

Question 3

Lewy bodies

Answer 3

Seen in lewy body dementia and parkinsons- Aggregates of alphasynuclein in round concentrically laminated pale eosinophilic cytoplasmic inclusions

Question 4

Asteroid bodies

Answer 4

Seen in sarcoidosis and berylliosis Acidic stellate inclusions in giant cells

Question 5

Barr bodies

Answer 5

Seen in stains of X chromasomes dark staining mass incontact with nuclear membranes

Question 6

Mallory bodies

Answer 6

Found in alcoholic hepatitis, alcoholic cirrhosis, Wilson’s disease and primary biliary cirrhosis- Alcoholic hyalin eosinophilic intracytoplasmic inclusions in hepatocytes : Intermediate filaments predominantly keratins

Question 7

Schauman bodies

Answer 7

Seen in sarcoidosis and berrylliosis- concentrically laminated inclusions of up to 50 micrometers in giant cells

Question 8

Zebra bodies

Answer 8

Seen in Niemann-pick disease, Tay sachs disease, or any mucopolysaccharidoses-Palisaded lamellated membranous cytoplasmic bodies seen in macrophages

Question 9

LE bodies

Answer 9

Seen in SLE- Nuclei of damaged cells with bound antinuclear antibodies which become homogenous and loose chromatin pattern

Question 10

Verocay bodies

Answer 10

Seen in Schwannoma- Pairs of nuclei at the end of a fibrillary bundle

Question 11

Hirano bodies

Answer 11

Seen in normal aging but more so in alzheimers disease Eosinophillic football shaped inclusions seen in neurons of the brain

Question 12

Neurofibrillary tangles

Answer 12

Seen in Alzheimers disease- Microtubule associated proteins and neurofilaments

Question 13

Kuru plaqques

Answer 13

Seen in Kuru and gerstman straussler syndrome and on occassion in patients with CJD- They are composed of a partly host encoded prion protein