Histology Lecture (Connective tissue) part 1 Flashcards
Support and bind tissues for all organs.
Connective Tissue
Provide packing tissue between organs.
Connective Tissue
Creates a hydrophilic environment.
Connective Tissue
Mediates exchange of substances b/w
blood and tissues.
Hydrophilic Environment
Mesodermal in origin.
Connective Tissue
Origin of connective tissue.
Mesoderm
Embyonic tissue.
Mesenchyme
Origin of different tissues w/c develop into
specialized cells of adult tissue.
Mesenchyme
Example of adult tissue that developed from mesenchyme.
- Connective Tissue
- Smooth Muscles
- Blood Cells
6 Main functions of Connective Tissue.
- Structural framework for the body.
- . Protection/mechanical support for all organs and tissues.
- Transport fluids and dissolves substances.
- Storage of energy.
- Protection of the body against infection.
- Significant role in repair or healing of wounds.
Composition of Connective Tissue
- Connective Tissue Cells
- Extracellular Matrix
2 types of connective tissue cells.
- Fixed Cells
- Free Mobile or Wondering Cells
Produce and maintain extracellular components and storage of reserve fuel.
Fixed Cells
5 cells under classified as fixed cells.
- Fibroblast
- Fixed Macrophages
- Adipose Cells
- Reticular Cells
- Undifferentiated Mesenchymal Cells
For short term tissue reaction to injury.
Free Mobile or Wondering Cells
5 cells under classified as free mobile or wondering cells.
- Macrophages
- Plasma Cells
- Mast Cells
- Eosinophils
- Lymphoid Cells
Bone marrow in origin.
Mast Cell
Produce Histamine.
Mast Cell
Help dilate small blood vessels in reaction to injury.
Histamine
3 compounds released by mast cell, which are involved in inflammatory responses.
- Heparin
- Histamine
- Chemical mediators
Inflammatory response cell/mast cell in liver.
Kupffer Cells
Inflammatory response cell/mast cell in CNS.
Microglia I cell
Inflammatory response cell/mast cell in bone.
Osteoclasts
Store triglycerides, support, protect and insulate.
Adipocytes
______________ store energy in the form of ______________.
- fat cells
- triglycerides
Activated form of fibroblasts.
fibroblasts
Inactivated form of fibroblasts.
Fibrocytes
Flat with fine granular cytoplasm.
Fibroblasts
Secrete both fibers and ground substance of the matrix.
Fibroblasts
Phagocytes that develop from Monocytes.
Macrophages
ECM turn over.
Macrophages
Phagocytosis of dead cells or debris.
Macrophages
Takes part in the antigen presentation to lymphocytes.
Macrophages
Shape of the nucleus of Macrophages.
oval and kidney-like
Antibody secreting cells that develop from B
Lymphocytes.
Plasma cell
___________ migrate from blood vessels to CT by ___________
- Leukocytes
- Diapedesis
All leukocyte except ___________ do not return to blood after entering CT
- Lymphocytes
acts for bacterial infection
Neutrophils
acts for allergic reaction
Basophils
acts for allergic reaction and parasitic infection
Eosinophils
3 granulocytes leukocytes
- Neutrophil
- Basophil
- Eosinophil
2 agranulocytes leukocytes
- Lymphocytes
- Monocytes
Pag nasa blood palang, ____________.
Pag nasa tissue na, ____________.
- Monocytes
- Macrophages
6 types of connective tissue cells
- mast cell
- adipocytes
- fibroblast
- macrophages
- Plasma cells
- leukocytes
3 types of connective tissue fibers
- Collagen fibers
- Elastic fibers
- Reticular fibers
Large fibers made of protein collagen typically the
most abundant fibers, do not branch
Collagen Fiber
Promote flexibility
Collagen Fiber
Intermediate fibers made of protein elastin
Elastic Fiber
Branching fibers that allow stretch and recoil
Elastic Fiber
Stained with aldehyde fuchsin
Elastic Fiber
Small delicate, branched fibers
Reticular Fiber
With same chemical composition as collagen
Reticular Fiber
Structural framework for organs e.g. spleen and lymph nodes
Reticular Fiber
Stained with silver stain
Reticular Fiber
Lubricant and barrier to invader.
Matrix Ground Substance
3 types of matrix ground substances.
- Hyaluronic Acid
- Chondroitin Sulfate
- Other Ground Substances
3 examples of other ground substances
- Dermatin Sulfate
- Keratin Sulfate
- Adhesion Proteins
Complex combination of polysaccharides and proteins found in “true” or proper connective tissue
Hyaluronic Acid
example of hyaluronic acid
GAG - glycosaminoglycans
The jellylike ground substance of cartilage, bone, skin and blood vessels
Chondroitin Sulfate
Types of connective tissue
- True or proper connective tissue
- Specialized connective tissue
2 types of specialized connective tissue
- Liquid Connective Tissue
- Supportive Connective Tissue
Classification of CT based on distribution
- Loose Connective Tissue
- Dense Connective Tissue
- Dense irregular Connective Tissue
- Dense regular Connective Tissue
8 Connective tissue with special properties
- Mucous Connective Tissue
- Elastic Connective Tissue
- Reticular Connective Tissue
- Adipose Connective Tissue
- Pigment
- Embyonal Connective Tissue
- Lymphoid or adenoid Connective Tissue
- Interstitial Connective Tissue- loose, dense
3 types of loose connective tissue
- Areolar Connective Tissue
- Adipose Connective Tissue
- Reticular connective Tissue
Composition:
- all 3 types of fibers
- several types of cells
- semi-fluid ground substance
Areolar CT
Distribution:
- subcutaneous layer
- mucous membranes
- around blood vessels, nerves, and organs
Areolar CT
Function:
- strength
- support
- elasticity
Areolar CT
Composition:
- it has Adipocytes
Adipose CT
“signet ring” appearing fat cells
Adipocytes
store energy in form of triglycerides (lipids)
Adipocytes
Distribution:
- subcutaneous layer
- around organs
- yellow marrow of long bones
Adipose CT
Function:
- supports
- protects
- insulates,
- serves as an energy reserve
Adipose CT
Location of Adipose Connective Tissue
- Hypodermis
- Abdomen
- Breasts
- Around kidneys and eyeballs
Composition:
- Fine interlacing reticular cell and fiber
Reticular CT
Distribution:
- liver
- spleen
- lymph nodes
Reticular CT
Functions:
- forms framework (stroma) of organs
- binds together smooth muscle tissue cells
Reticular CT
Location:
- Lymphoid organs: lymph nodes, bone
marrow, and spleen
Reticular CT
3 types of dense CT
- Dense Regular Connective Tissue
- Dense irregular Connective Tissue
- Dense Elastic Connective Tissue
Composition:
- Primarily collagen fiber
- Few elastic fiber
Dense Regular CT
Dominant cell in Dense regular CT
Fibroblast
Location:
- Tendons
- ligaments
- aponeuroses
Dense Regular CT
Composition:
- Irregularly arranged collagen fiber
- Some elastic fiber
Dense Irregular CT
Location:
- Fibrous capsules of organs and of joints
- dermis of the skin
- submucosa of the digestive tract
Dense Irregular CT
Composition:
- Contains high proportion of elastic fiber
Dense Elastic CT