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Histology - Exam #1 > Histology Lecture 5: CAMs and Junctional Complexes > Flashcards

Histology Lecture 5: CAMs and Junctional Complexes Flashcards

1
Q

a sheetlike extracellular matrix in direct contact with epithelial cell surfaces; results from the self-assembly of laminin molecules with type IV collagen, entactin, and proteoglycans

A

basal lamina

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2
Q

formed by type III collagen fibers, supports the basal lamina and is continuous with the connective tissue

A

reticular lamina

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3
Q

separates an epithelial layer from its connective tissue support; PAS+

A

basement membrane

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4
Q

part of the basement membrane produced by the epithelium

A

basal lamina

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5
Q

part of the basement membrane produced by the connective tissue

A

reticular lamina

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6
Q

does not form fibrils and is produced by epithelial cells

A

Type IV Collagen

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7
Q

forms fibrils and is secreted by fibroblasts

A

Type I Collagen

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8
Q

major component of the basal lamina with binding sites for integrins, type IV collagen, entactin, and proteoglycans

A

Laminin

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9
Q

Components of the basal lamina

A

Laminin, Fibronectin, Type IV collagen, entactin (nidogen) and proteoglycans

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10
Q

cross shaped protein consisting of three chains (alpha, beta, and gamma); can associate with one another and form a meshlike polymer (i.e matrix)

A

laminin

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11
Q

two protein chains crosslinked by disulfide bridges; the main adhesion molecule of the extracellular matrix; produced by fibroblasts; binding sites for proteoglycans, integrins, collagen, and fibrin

A

fibronectin

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12
Q

calcium dependent cell adhesion molecules

A

cadherins and selectins

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13
Q

calcium independent cell adhesion molecules

A

integrins and immunoglobulin superfamily molecules

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14
Q

link two cell’s cytoskeletons together; form cis- homophilic dimers via HVA binding face when Calcium ion binds

A

E-cadherin

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15
Q

found along the lateral surface of the cell and involved with the maintenance of most epithelial layers

A

E-cadherin

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16
Q

loss is assocated with invasive behaviour of tumour cells

A

E-cadherin

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17
Q

small proteins that link cytoplasmic end of a cadherin with cytoplasmic actin

A

catenin

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18
Q

attached to cytoplasmic end of cadherin;

A

beta and gamma catenin

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19
Q

binds directly to cytoplasmic actin

A

alpha catenin

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20
Q

serve as a major interface between the cadherins that hold adjacent cells together and the actin cytoskeletons of those cells

A

catenins

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21
Q

bind to carbohydrates and are involved with the movement of leukocytes from blood into tissue (extravasation)

A

selectins

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22
Q

selectins associated with platelets and activated endothelial cells lining blood vessels

A

p-selectin

23
Q

selectins associated with activated endothelial cells

A

e-selectins

24
Q

selectins associated with leukocytes

A

l-selectins

25
Q

a specific oligosaccharide ligand for P-selectin associated with leukocyte extravasation

A

sialy Lewis-x antigen

26
Q

glycoproteins mainly involved with cell-extracellular matrix interactions; link the cell to the extracellular matrix; bind both cytoskeleton and extracellular matrix

A

integrins

27
Q

sequence in fibronectin and laminin that interact with extracellular domain of integrins

A

RGD

28
Q

Members of this family possess an extracellular segment with one or more folded domains characteristic of
immunoglobulins

A

Immunoglobulin superfamily

29
Q

These are molecular complexes that anchor cells together and reinforce the physical integrity of tissues and the cells that make up the tissues; can be found on the basolateral surfaces of epithelial cells

A

adherens

30
Q

These are molecular complexes that establish an impermeable barrier between adjacent cells, especially epithelial cells, that prevents paracellular transport and maintains concentration differences between the environments on either side of the epithelial sheets

A

occludens

31
Q

These are composed of molecular pores that enable cells to rapidly exchange ions and small molecules that help coordinate activities among the cells that make up the tissue

A

gap junctions

32
Q

complexes that travel all the way around the circumference of the cell and link all neighboring cells to the central cell. They are sometimes referred to as belt-like complexes; associated with intracellular actin

A

zonula

33
Q

a “spot” or snap-like junction. They are of the adherens
variety and are often referred to as desmosomes (associated with the lateral domains of epithelial cells) or hemidesmosomes (associated with the basal domain of epithelial cells). They are associated with intracellular intermediate filaments (tonofilaments).

A

Macula

34
Q

anchoring junctions characterized by intercellular spaces filled with cadherin proteins (desmogleins and desmocollins)

A

adherens

35
Q

autoantibodies to desmoglein 1 cause this

A

pemphigus foliaceus

36
Q

autoantibodies to what cause pemphigus foliaceus

A

desmoglein 1

37
Q

make up cytoplasmic plaques

A

desmoplakin and plakoglobin

38
Q

a spotlike junction associated with keratin intermediate filaments
(also known as tonofilaments ) extending from one spot to another on the lateral and basal cell surfaces of epithelial
cells

A

macula adherens/desmosome

39
Q

associated with actin microfilaments

A

zonula adherens

40
Q

anchoring junctions that anchor the basal domain of the epithelial cell to the basal lamina

A

hemidesmosome

41
Q

provide a barrier against the paracellular transport pathway whereby solutes and fluids are transported from one side of an epithelial barrier to the opposite side by passing between the cells

A

occluding junctions/tight junctions

42
Q

transmembrane proteins associated with the junctional complex and are responsible for the occlusive properties of the tight junction; they attach intracellularly to zonula occludens proteins ZO-2 and ZO-3

A

claudins and occludins

43
Q

members of the immunoglobulin superfamily. They are stabilized by disulfide bonds and form cishomodimers that facilitate cell adhesion

A

Junctional Adhesion Molecules and Nectin

44
Q

associated with afadin (intracellular molecule)

A

Nectin

45
Q

associated intracellularly with afadin and ZO-1

A

JAMs

46
Q

spots that anchor the cell to the extracellular matrix via integrins; differ from desmosomes because the intracellular attachment is to actin microfilaments via connecting proteins instead of tonofilaments

A

focal adhesions

47
Q

close when calcium ion concentrations are high

A

gap junctions

48
Q

type of collagen most associated with the basal lamina

A

Type IV

49
Q

type of cell adhesion molecules is associated with zonula occludens and desmosomes

A

cadherins

50
Q

Desmocolloin and desmogleins belong to which of the following groups of CAMs

A

cadherins

51
Q

seve as a major interface between the cadherins that hold adjacent cells together and their actin cytoskeletons

A

catenins

52
Q

The extracellular domains bind to molecules in the extracellular matrix such as fibronectin and laminin

A

integrins

53
Q

molecular complexes that anchor cells together and reinforce the physical integrity of tissues and the cells that make up the tissue

A

zonula adherens

54
Q

molecular complexes that primarily serve to prevent paracellular
transport

A

zonula occludens

Histology - Exam #1 (9 decks)

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