Histology Flashcards
1
Q
List characteristics of squamous cell carcinomas
A
- Keratin production
- Intercellular bridges
- Arises in areas covered by squamous epithelium (vagina, oesophagus, head and neck, skin, anus)
2
Q
List characteristics of adenocarcinomas
A
- Mucin production
- Forms glands
- Breast, pancreas, lungs, stomach, colon
3
Q
List main types of histochemical stain
A
- Prussian blue iron stain positive for haemochromatosis
- Congo red positive amyloid. When birefringed appears apple green.
- Infections (Ziel Neelson Acid Fast)
4
Q
Describe how immunohistochemical stains work
A
- One antibody (rabbit antigen) added to detect the antigen
- A second antibody (goat anti-rabbit) which binds to constant region of the antigen and has fluorescent tag
5
Q
List examples of immunohistochemical stains
A
- Cytokeratin epithelial marker
- CD45 lymphoid marker
- Liver metastasis can be identified by immunohistochemical stain.
- CK7 positive CK20 negative colorectal cancer
- Used in infections (eg. herpes simplex)
