Histology Flashcards

1
Q

Layers of the heart

A
  1. Epicardium
  2. Myocardium
  3. Endocardium
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2
Q

Epicardium

A

Simple squamous epithelium (mesothelium)

Thin layer of (fibroelastic) CT and fat

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3
Q

Myocardium

A

Cardiac muscle fibres (striated) in different planes to close down lumen chamber

  • Central rounded nuclei
  • Intercalated discs
  • Rich capillary bed
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4
Q

Endocardium

A

Simple squamous epithelium that lines the atria, ventricles and valves

  • Underlying basement membrane
  • Small layer of loose CT and adipose tissue
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5
Q

Elastic aorta examples

A

Aorta

Pulmonary trunk

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6
Q

Elastic artery function

A

Large conducting vessels that act as pressure reservoirs by stretching during systole
- Pressure falls during diastole and the artery recoils maintaining pressure on the blood

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7
Q

Elastic artery histology

A

Vasa vasorum in T. adventitia

Elastic fibre laminae (elastin secreted by smooth muscle cells) in T. media

Single layer of endothelial cells with elastin rich collagen supporting layer in T. intima

  • Fibroblasts and myointimal cells
  • Accumulate lipid with ageing
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8
Q

Muscular artery function

A

Distributing vessels

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9
Q

Muscular artery histology

A

T. adventitia contains collagen and elastin.
- External elastic layer

Thick T. media primarily smooth muscle (no elastic laminae), elastin and collagen
- Internal elastic layer

T. intima is flattened endothelial cells

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10
Q

Arteriole function

A

Terminal branches which supply blood to capillary bed (local) and control blood pressure (systemic)

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11
Q

Arteriole histology

A

T. adventitia merges with surrounding tissue
- No EEL

Only 1-2 layers of smooth muscle for T. media
- No IEL

T. intima is simple squamous epithelium

Rich sympathetic innervation
Diameter: 100-300 um

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12
Q

Capillary function

A

Main site of exchange for nutrients and gases

  • Low blood pressure
  • Very thin-walled
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13
Q

Capillary histology

A

T. Intima only
Diameter 3-4 um
- Endothelium on BM

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14
Q

Pericytes

A

Incomplete layer of cells surrounding BM have contractile properties to control blood flow

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15
Q

Continuous capillaries

A

Materials must pass through cell or between cell
Selective transport mechanisms
- E.g. muscle

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16
Q

Fenestrated capillaries

A

Have fenestrations/pores (up to 100 um)

  • With or without protein diaphragms (filter by MW and/or charge)
  • e.g. endocrine glands, renal corpuscle
17
Q

Discontinuous

A

Gaps between endothelial cells (and BM) which allows free movement of fluid and cells
- e.g. liver, spleen, bone marrow

18
Q

Sinusoids

A

Large diameter discontinuous capillaries. Found where large amount of exchange occurs (e.g. liver)
- T. Intima contains phagocytic cells

19
Q

Venule histology

A

T. adventitia fuses with surrounding tissue

1 or 2 layers of smooth muscle in the T. media

Clear T. intima without elastic fibres

  • Diameter: 8-100 um
20
Q

Veins

  • Superficial
  • Deep
A

Superficial: thick walled, no surrounding support
Deep: thin walled, surrounding support from deep fascia and muscles

21
Q

Vein histology

A

T. adventitia is the broadest layer containing longitudinal collagen fibres and vasa vasorum.

T. media contains 2-3 layers of muscle cells

T. intima is thin and folds produce valves

IEL and OEL thin or absent

22
Q

Muscular vein histology

A

T. adventitia contain vasa vasorum

T. media: thick muscular wall

T. intima: simple squamous endothelial cells

IEL and OEL absent

23
Q

Lymphatic system function and histology

A

Drains tissue fluid lost from blood capillaries and returns to systemic circulation

  • Nodes present alongside major veins
  • Valves direct flow
24
Q

Lymph capillary histology

A

Endothelium very thin.
No fenestrations
Absent or rudimentary basal lamina
Anchoring filaments (collagen link endothelial cell to surrounding tissue)
No RBCs
- Lumen maintained at negative hydrostatic pressure