Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Drugs Step 1 > Histology > Flashcards

Histology Flashcards

1
Q

Fibrofatty replacement of muscle

A

Duchenne Muscular Dystrophy

  • Frameshift
  • Pseudohypertrophy of Calf muscle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Uniformly enlarged uterus

Secretory endometrium - not pregnant

A

Endometrial glandular tissue in myometrium = Adenomyosis

  • Heavy menstrual bleeding
  • Dysmenorrhea
    • endometrial tissue growth in confined myometrial space
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Upper glandular layer of gastric body & fundus

A

Parietal cells located here - second layer from top

  • Intrinsic factor & pernicious anemia
  • get B12 deficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Deeper aspect of gastric glands

- small basophilic granular cells

A

Chief cells - pepsinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Large hepatocytes filled with finely granular, homogeneous pale pink cytoplasm

A

Hepatitis B
- accumulation Hep B surface antigen = granulations
- dull eosinophilic inclusions = pale pink
Could see ballooning degeneration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Last to disappear in lungs?

A

Cilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

First sign of puberty in girls?

A

Breast bud development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Immature squamous cell w/ dense, irregularly staining cytoplasm and perinuclear clearing = halo
Enlarged, pyknotic nucleus, condensed chromatin = raisinoid appearance

A

Koilocytes

- HPV - likes true vocal cords (stratified squamous epith)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Facial and periorbital edema

A

Post Strep GN

- granular deposits of IgG, IgM and C3 along BM & in mesangium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Villous atrophy, crypt hyperplasia

A

Celiac disease - do duodenal biopsy

- Brunner’s glands only in duodenum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q 
Connexin-43 & Oxytocin receptor
vs.
Claudins, occludin
vs. 
Cadherins
A

Gap junctions

Tight junctions

Adherens junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Muscle tissue w/ patch of non-red cells (purplish)
Plump MF’s w/ abundant cytoplasm
Central, slender shromatin ribbons

A

Anitschkow (catepillar) cells = Acute Rheumatic Fever

- seen w/ cardiac biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

LM: widespread glomerular lesions w/ focal necrosis & crescent formation
IF: ??

A

Rapidly Progressive GN:

  • Parietal cells, monocytes, MF + fibrin
  • think Crescent
  • think Goodpasture, type IV collagen in BM

IF = IgG and C3 linear deposition along BM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Irreversible airspace dilation distal to terminal bronchioles

A

MF and Neutrophils released proteases (like elastin) that degraded the extracellular matrix, generated ROS, acing wall destruction.
Centriacinar EMphysema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Papillary cells w/ fibrovascular core

A

Intraductal Papilloma

  • nipple discharge: thin straw-like, bloody
  • may see focal atypic/ductal carcinoma in situ
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Eosinophilic cytoplasm and loss of Nissl substance

A

Cerebellar insult 12-24 hours ago
- Red neurons

Liquefactive necrosis 1 week - 1 month

17
Q

Bilateral complex ovarian masses with solid & cystic components
- stomach wall thickening & ovarian masses
Also???

A

Gastric + Ovarian = Krukenberg tumor

  • primarily gastric cancer that migrates to ovary
  • see Signet Ring Cells = tons of mucin displacing the nucleus
18
Q

Dilated, coiled endometrial glands & edematous stroma

A

Ectopic pregnancy

  • 2cm mass in left adnexa
  • thickened endometrial stripe
19
Q

EM Subepithelial humps

IF: ???

A

Granular deposits of IgG, IgM and C3 on BM

- post strep GN

20
Q

MI one year ago shows what collagen?

Seven days after??

A

Type I collagen - like bone, tendons, ligaments, dentin, cornea, scar tissue

Granulation (7 days) is type III collagen

21
Q

Septal myocyte hypertrophy
Myofiber disarray - abnormally shaped myocytes
Bizarre nuclei and increased CT

A

Hypertrophic cardiomyopathy

- death young athletes; v-fib

22
Q

Myocyte hypertrophy & haphazardly arranged myocytes and myocyte bundles
Interstitial spaces prominent – fibrosis

A

Hypertrophic cardiomyopathy

23
Q

Tumor associated with Polyvinyl chloride, arsenic, or thorotrast
Stain positive for CD 31

A

Liver angiocarcoma

  • CD31 = PECAM1
  • means tumor arose from vascular endothelial cells
24
Q

Pink, spider-like lesions on oral & nasal mucosa + face

A

Telangiectasis - Osler-Weber-Rendu syndrome

- rupture of these cause epistaxis, GI bleed, hematuria

25
Q

Café-Au-Lait + Lisch nodules + ______ = ???

A

+ neurofibromas = NF1

26
Q

Hemangioblastomas

  • where?
  • syndrome?
  • other masses?
A

Retina & cerebellum
Congenital cysts/neoplasms kidney, liver, pancreas
Von Hippel-Lindau
Risk for Renal cell carcinoma

27
Q

Ducts distended by pleomorphic cells

- prominent central necrosis

A

Ductal carcinoma in situ

- precursor to invasive ductal carcinoma #1 breast cancer

28
Q

Small cuboidal cells in sheets
Gland-like structures w/ acidophilic material
Microfollicular pattern around pink, eosinophilic center

A

Granulosa cell tumor of ovary = Call Exner bodies

  • increased Estrogen
  • increased inhibit
  • *clitoromegaly

Drugs Step 1 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions