Final Step 1

Question 1

Signet Ring Cells

Answer 1

Krukenberg

Lobular carcinoma in situ LCIS

Question 2

Ductal carcinoma in situ

Answer 2

DCIS

- caseous necrosis

Question 3

Lobular carcinoma in situ

Answer 3

LCIS

• signet ring cells
• ER+ and PR+ (estrogen receptor, progesterone)

Question 4

Large tumor in breast with leaf-like projections

Answer 4

Phyllodes tumor

• women in 50’s
• mostly benign

Question 5

Firm, rock-hard, fibrous mass
Fixed, immobile
Stellate, star-like pattern

Answer 5

Invasive ductal carcinoma
#1 breast mass in postmenopausal women
Worst prognosis, most common malignant

Question 6

Multiple and bilateral nodules in breast

Answer 6

Invasive lobular

• often multiple lesions in same location
• decreased E-cadherin expression
• orderly row of cells on histo

Question 7

Nasty, eczematous patches in nipple, areola

Answer 7

Paget disease of breast

Question 8

Most common benign breast tumor

Answer 8

Fibroadenoma - fluctuates with hormones

Question 9

Non-Proliferating breast disease w/ blue dome cyst

Answer 9

Cystic or Fibrocystic change

Question 10

Nipple discharge, straw/bloody

Answer 10

Intraductal papilloma
Proliferation of papillary cells in a duct or cyst
- w/ fibrovascular core

Question 11

Antibodies to splicesomal snRNP’s

Answer 11

Anti-Smith Antibodies: specific for SLE

• pre-mRNA splicing snRNP’s sit on pre-mRNA
• Lariat loop generated
• Lariat released to remove intron & join entrons

Question 12

Cut in carpal tunnel surgery:

Answer 12

Transverse carpal ligament

- releases tension on medial nerve