Histamine, Serotonin, Ergot alkaloids, Eicosanoids Flashcards
1
Q
Diphenhydramine
A
- Reversible H1 blockers.
- Use: allergy, motion sickness, sleep aid.
- Tox: Sedation, antimuscarinic, anti-α-adrenergic.
2
Q
Dimenhydrinate
A
- Reversible H1 blockers.
- Use: allergy, motion sickness, sleep aid.
- Tox: Sedation, antimuscarinic, anti-α-adrenergic.
3
Q
Chlorpheniramine
A
- Reversible H1 blockers.
- Use: allergy, motion sickness, sleep aid.
- Tox: Sedation, antimuscarinic, anti-α-adrenergic.
4
Q
Cetirizine
A
- 2nd gen: H1 blocker
- Use:Allergy
- no anti-muscarinic activity = dec. entry into CNS
5
Q
Loratadine, fexofenadine, desloratadine
A
- 2nd gen: H1 blocker
- Use:Allergy
- no anti-muscarinic activity = dec. entry into CNS
6
Q
Sumatriptan
A
- 5-HT(1B/1D) agonist.
- induces vasoconstriction (Half-life < 2 hours)
- Use: acute migraines, cluster headaches
- Tox: coronary vasospasm, mild tingling.
7
Q
Ondansetron
A
- 5-HT(3) antagonist; central-acting antiemetic.
- Use: Control vomiting postop and in chemotherapy.
- Tox: Headache, constipation.
8
Q
LTB 4
A
- chemotactant in inflammation
- Use: no clinical application
9
Q
LTC 4, LTD 4
A
- Bronchoconstrictors important in anaphylaxis, cause edema.
- Use: no clinical application
10
Q
TXA2
A
- platelet aggregation, vasoconstriction
- Use: no clinical application
11
Q
PGI 2 : epoprostenol
A
-prostacyclin analog: vasodilation, reduces platelet
aggregation (opposite of TXA2).
-Use: Vasodilator in pulm HTN, antiplatelet agent in
extracorporeal dialysis.
-Tox: Hypotension, flushing, headache (all due to vasodilation).
12
Q
PGE 1 derivative: misoprostol
A
- increased HCO 3 and mucus secretion in stomach, uterine contraction, maintain PDA.
- Use: antidote to aspirin induced ulcer, abortifacient, maintain PDA (used in disposition of great vessels).
- Tox: Diarrhea, uterine cramping
13
Q
PGF 2 derivative: latanoprost
A
- Increases outflow of aqueous humor, reduces intraocular pressure
- Use: glaucoma
- Tox: color change in iris.
