Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Unit 2 > Histamine & Serotonin > Flashcards

Histamine & Serotonin Flashcards

1
Q

Diphenhydramine (Benadryl)

A

Class: Ether/ethanolamine derivitive
MOA: H1 receptor antagonist
Uses: Allergy symptom relief
SE: Anti-muscarinic, sedating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Tripelennamine (Pyribenzamine)

A

Class: Ether/ethanolamine derivitive
MOA: H1 receptor antagonist
Uses: OTC sleep aid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cyclizine (Marezine)

A

Class: Piperazine derivative
MOA: H1 receptor antagonist
Uses: Motion sickness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Promethazine (Phenergan)

A

Class: Phenothiazine derivative
MOA: H1 receptor antagonist
Uses: Antiemetic
SE: Anti-muscarinic, sedating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Chlorpheniramine (Chlor-Trimeton)

A

Class: Alkylamine derivitive
MOA: H1 receptor antagonist
Uses: Component of “cold” medications
SE: Less sedating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Loratadine (Claritin)

A

Class: Piperidine derivitive
MOA: 2nd generation H1 receptor antagonist
Uses: Allergic rhinitis
SE: Cardiovascular effects (rare, with high doses)
Misc: Poorly crosses BBB, so fewer central and side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fexofenadine (Allegra)

A

Class: Piperidine derivitive
MOA: 2nd generation H1 receptor antagonist
Uses: Allergic rhinitis
SE: Cardiovascular effects (rare, with high doses)
Misc: Poorly crosses BBB, so fewer central and side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Azelastine (Astelin)

A

Class: Piperidine derivitive
MOA: 2nd generation H1 receptor antagonist
Uses: Allergic rhinitis (intranasal spray), allergic conjunctivitis (ophthalmic solution)

Misc: Poorly crosses BBB, so fewer central and side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cetirizine (Zyrtec)

A

Class: Piperidine derivitive
MOA: 2nd generation H1 receptor antagonist
Uses: Allergic rhinitis

Misc: Poorly crosses BBB, so fewer central and side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cimetidine (Tagamet)

A

MOA: H2 receptor antagonist; blocks gastric acid secretion (more so with nocturnal acid secretion than meal secretion)
Uses: Dyspepsia, duodenal and gastric ulcers, hypersecretory conditions
SE: Antiandrogen (causing impotence and gynecomastia), inhibition of P450 enzymes; CNS dysfunction possible
Misc: Most side effects of H2-blocker class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ranitidine (Zantac)

A

MOA: H2 receptor antagonist; blocks gastric acid secretion (more so with nocturnal acid secretion than meal secretion)
Uses: Dyspepsia, duodenal and gastric ulcers, hypersecretory conditions
SE: Liver toxicity; CNS dysfunction possible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Famotidine (Pepcid)

A

MOA: H2 receptor antagonist; blocks gastric acid secretion (more so with nocturnal acid secretion than meal secretion)
Uses: Dyspepsia, duodenal and gastric ulcers, hypersecretory conditions
SE: CNS dysfunction possible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Nizatidine (Axid)

A

MOA: H2 receptor antagonist; blocks gastric acid secretion (more so with nocturnal acid secretion than meal secretion)
Uses: Dyspepsia, duodenal and gastric ulcers, hypersecretory conditions
SE: CNS dysfunction possible
Misc: Least side effects of H2-blocker class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cyproheptadine (Periactin)

A

MOA: Antihistaminic and antiserotinergic
Uses: Skin allergies (urticaria, anti-5HT1), diarrhea of carcinoid syndrome (anti-5HT2)
SE: Sedation, antimuscarinic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ketanserin

A

MOA: Selective 5HT2A,2C receptor antagonist, as well as α1 and H1 receptor antagonist
Uses: Antihypertensive (relaxes vascular and tracheal smooth muscle), antiplatelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ondansetron (Zofran)

A

MOA: 5HT3 receptor antagonist
Uses: Nausea and vomiting in chemotherapy

17
Q

Ergotamine (Ergomar)

A

Class: Ergot alkaloid
MOA: Nonspecific partial agonist at all 5HT1,2 receptors; partial agonist at α-adrenergic receptors
Uses: Prodrome of migraines
SE: N/V, cumulative and prolonged vasoconstriction

18
Q

Methysergide (Cycloset)

A

Class: Ergot alkaloid
MOA: Partial agonist at all 5HT1 receptors, antagonist at 5HT2
Uses: Prophylaxis of migraines
SE: GI disturbances, inflammatory fibrosis (chronic use), hallucinations
Misc: Withdrawn from U.S. market

19
Q

Ergonovine

A

Class: Ergot alkaloid

Uses: Postpartum hemorrhage (Oxytocic)

20
Q

Bromocriptine (Sansert)

A

Class: Ergot alkaloid
MOA: Dopamine agonist
Uses: Hyperprolactinemia

21
Q

Triptans

A

Class:Non-ergot serotonin analogs
MOA: 5HT1B,D receptor agonist
Uses: Effective (70%) migraine treatment

Pharm Unit 2 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions