Adrenergic Receptor Agonists

Question 1

Norepinephrine (Levophed)

Answer 1

Class: Non-selective agonist
MOA: Agonist: α1, α2, β1
Uses: Acute Hypotension
SE: Hypertension; arrythmias; headache

Question 2

Epinephrine

Answer 2

Class: Non-selective agonist
MOA: Agonist: α1, (α2), β1, β2
Uses: Anaphylactic shock; combined with local anesthetics; glaucoma
SE: Palpitation; arrhythmias; headache

Question 3

Amphetamine

Answer 3

Class: Indirect acting
MOA: Increases release of NE
Uses: ADHD, narcolepsy, recreation
SE: Hypertension, insomnia, anxiety, arrhythmias

Question 4

Isoproterenol (Isuprel)

Answer 4

Class: Non-selective β agonist
MOA: Agonist: β1, β2
Uses: shock; heart block
SE: Palpitation; tachyarrhythmia; headache

Question 5

Dobutamine

Answer 5

Class: β1-selective β agonist
MOA: Agonist: β1
Uses: Cardiac decompensation; shock; heart block
SE: Tachyarrythmias; hypertension

Question 6

Albuterol (Proventil)

Answer 6

Class: β2-selective β agonist
MOA: Agonist: β2
Uses: Prevent or reverse exercise-induced bronchospasm; mild asthma; COPD
SE: Can mask progressively severe inflammation; Tachycardia; muscle tremor

Question 7

Terbutaline (Brethine)

Answer 7

Class: β2-selective β agonist
MOA: Agonist: β2
Uses: Prevent or reverse exercise-induced bronchospasm; mild asthma; COPD; early labor
SE: Can mask progressively severe inflammation; Tachycardia; muscle tremor

Question 8

Phenylephrine (Neo-Synephrine)

Answer 8

Class: α1-selective α agonist
MOA: Agonist: α1
Uses: Nasal congestion; postural Hypotension
SE: Hypertension; reflex bradycardia

Question 9

Clonidine (Catapres)

Answer 9

Class: α2-selective α agonist
MOA: Agonist: CNS α2
Uses: Hypertension; shock; withdrawal from drug dependence
SE: Sedation

Question 10

α-methyldopa (Aldomet)

Answer 10

Class: α2-selective α agonist
MOA: Metabolite (α-methylnorepinephrine) activates CNS α2 receptors
Uses: Hypertension
SE: Sedation
Misc: Prodrug; crosses BBB

Question 11

Fenoldopam (Corlopam)

Answer 11

Class: Selective dopamine agonist
MOA: Agonist: D1 only
Uses: Increase blood flow at renal, mesenteric, and cerebral arteries

Question 12

Dopamine

Answer 12

Class: Mixed acting (direct/indirect)
MOA: Agonist: D1, α1, β1
Uses: Shock, renal failure, hypotension
SE: Vasoconstriction (@ high doses)
Misc: Low dose = Direct @ D1 Receptors
Medium dose = Direct @ Beta 1, some Indirect
High dose = Direct @ Alpha 1, some Indirect