Histamine (H2) Receptor Antagonists

Question 1

Histamine (H2) Receptor Antagonists General Mechanism of action/use

Answer 1

• suppress secretion of gastric acid

- alleviate heartburn, prevent complications in PUD, prevent ulcers, promote healing of gastroesophageal reflux disease

Question 2

Histamine (H2) Receptor Antagonists contraindications

Answer 2

• hypersensitivity

- impaired renal or hepatic function

Question 3

Cimetidine (Nursing Considerations)

Answer 3

• food reduces the rate of absorption
• cimetidine and antacids should be taken 1 hour apart
• reduce dosage in clients w/ renal impairment
• penetrates the BBB - CNS SE (mental confusion, agitation)

Question 4

Ranitidine, Famotidine and Nizatidine (nursing considerations)

Answer 4

• not affected by food
• side effects uncommon in Ranitidine
• Ranitidine does not penetrate the BBB