Histamine / Autacoids

Question 1

Migrain

Answer 1

Mild to Moderate- NSAIDS
Acute Severe- Triptan (Suma,Nara,Riza,Ele,Frova)
Other for Acute Severe- Ergotamine

Question 2

Prophylaxis for Migraine

Answer 2

A-
* Antidepressants (Imipramine)
* Anti epileptic (Valproate)
B-
* Beta blocker (Propanolol)
C-
*CCB (Flunarizine)
*CGRP antagonist (Erenumab, Eptinizumab, Fremanizumab, Galconizumab)
M-
Methysergide

Question 3

Other drugs for migraine

Answer 3

DITANS- (Lasmiditan)
CGRP Antagonist- (Olcegaptan, Rimegeptan, Ubrogeptan)

Question 4

Types Of Autacoids

Answer 4

Peptide- Angiotensin, Bradykinin
Amine- Histamine, Serotonin
Lipid- Leukotrienes, Prostaglandin, Thromboxane

Question 5

Types Of Histamine Receptor

Answer 5

H1- CNS/Bronchus- Allergy, Bronchoconstriction, Promote wakefulness
H2- Stomach- Acid secretion- Cemitidine, Rantidine
H3- Pre Synaptic- Break- Tiprolisant, Pitolisant
H4- WBC- Chemotaxis

Question 6

H1 1st Gen blockers

Answer 6

Promethazine
Diphenhydramine
Dimenhydrinate
Pheniramine
Chlor-pheniramine
Cyclazine
Cinnarizine

Question 7

H1 2nd Gen blocker

Answer 7

Fexofenadine
Loratidine
Des-Loratidine
Cetirizine
Levo-Cetirizine
Azelastin
Olopatadine

Question 8

Serotonin Receptor

Answer 8

5HT1A- Presynaptic- Break - Buspirone- Anxiety
5HT1B/1D- Blood Vessel- Vasoconstriction- Triptans, Ergotamine- Migraine
5HT2A/2C- Brain- Blockers- Clozapine, Olenzapine
5HT3- CTZ Centre- Ondensetron, Granisetron, Topisetron, Dolasetron, Palonosetron
5HT4- GIT- Prokinetic- Cisapride, Mosapride, Prucalopride