ANS

Question 1

Para Sympathetic System Drugs

Answer 1

Decrease Parasympathetic Action:-
1.Hemicholinium- Decreased choline reuptake
2.Vesamicol- Prevent entry of choline in vesicle
3.Botulinum Toxin- Prevent release of Ach
Increase Parasympathetic Action
Physostigmin- Inhibit Ach esterase activity.

Question 2

Cholinergic Drugs (Directly Acting)

Answer 2

Pilocarpine [M3]- Pupil- Miosis- ACG
Bethanechol [M3]- Bladder- Increase Output- Atonic Bladder
Methacholine- [M2]- Heart- Decreased Heart Functions- Tachy, Arrhythmia
Carbachol- Both nicotinic and muscarinic receptor.

Question 3

Cholinergic Drugs (Indirectly Acting Reversible Drugs)

Answer 3

Lipid Soluble- Physostigmin
[Alzheimers Drugs- Donepezil, Galantamin, Rivastigmin]

Water Soluble- Neostigmine
Pyridostigmin
Edrophonium

Question 4

Cholinergic Drugs (Indirectly Acting Irreversible Drugs)

Answer 4

Organophosphate/Carbamate Poisoning-
S- Salivation
L- Lactrimation
U- Urination
D- Diarrhoea
G- GI upset
E- Emesis
Rx- Atropine(2mg until sign of Atropinisation)
- Parlidooxime (PAM)
- Di acetyl monoime (DAM)

Question 5

Anticholinergic Drugs

Answer 5

[M1]Stomach- Pirenzapine, Telenzapine
[M2]Heart- Atropine
[M3]Bronchus- Ipratropium, Tiotropium
[M3]Glands- Glycopyrolate, Atropine
[M3]Pupil- Atropine, Homatropin, Cyclopentolate, Tropicamide
[M3]Bladder- Solfenacin, Oxybutyrin, Flavoxate, Trospium, Tolterodin, Darifenacin
[M3]Smooth Muscle- Hyoscine, Oxybutyrin,
[M1,M2,M3]CNS- Hyoscin(Scopolamin), Benzhexol, Benzatropin, Biperiden

Question 6

Atropine Poisoning

Answer 6

D-Dry Mouth, Delirium
H-Hyperthermia
A-Agitation
T-Tachycardia
U-Urinary
R-Retention
A-Accommodation lost

Question 7

Drugs Acting On Adrenergic Pathway

Answer 7

Metyrosin
Reserpine
Guanethidine
Cocaine

Question 8

Adrenergic Drugs (Indirectly)

Answer 8

1. Reuptake Inhibitor- Cocaine
   - TCA
2. Act by displacement- Tyramine
   - Ephedrine
   - Pseudoephedrine
   - Amphetamines

Question 9

Adrenergic Drugs (Directly Acting Catecholamine)

Answer 9

Endogenous- 1.Dopamine[D1,beta1,alpha1]
2.Adrenaline[alpha1,alpha2,beta1,beta2]
3.Noradrenaline[alpha2,beta1,beta2]
Exogenous-
1.Dobutamin[D1,beta1]
2.Dopexamine[D1,beta1,beta2]
3.Fenoldopam[D1]
4.Isoprenaline[beta1,beta2]

Question 10

Adrenergic Drugs (Directly Acting Non Catecholamine)

Answer 10

Alpha1:-
1. Xylometazoline
2. Oxymetazoline
3. Naphozoline
4. Phenylephrine eye drops
5. Methoxamine
6. Midodrine
7. Meohentermine
Alpha 2:-
1. Clonidine
2. Methyldopa
Beta 2 :-
1. Salbutamol
2. Formetrol
3. Salmetrol
4. Terbutalin
Beta 3:-
1. Mirabegron
2. Vibegron

Question 11

Anti Adrenergic Drugs (Non Selective)

Answer 11

Irreversible:- Phenoxybenzamine
Reversible:- Tolazoline, Phentolamine

Question 12

Anti Adrenergic Drugs (Selective Alpha 1)

Answer 12

Prazosin
Terazosin
Doxazosin
Alfuzosin
Alpha 1a blocker- Silodosin, Tamsulosin