Hist for Path: 2 Flashcards

1
Q

What do afferent arterioles arise from?

A

Interlobular arteries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do efferent arterioles arise from?

A

Glomerular capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is mesangial matrix?

A
  • Area in glomeruli between capillaries that holds them together
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is name of smooth muscle in glomeruli that regulates blood flow and filtration?

A
  • Mesangium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 functions of mesangium?

A
  1. Contraction to regulate flow: smooth muscle cell
  2. Structural support
    3 Phagocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where are the fenestrations found?

A
  • Cell walls of endothelial cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does basement membrane divide?

A

Endocapillary: mesangial
Extracapillary: Urinary space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is in visceral epithelium?

A

Podocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is in between foot processes of epithelium?

A

Slit diaphragm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the glomerular filtration barrier?

A

“Glomerular basement membrane” made of:

  1. Basal lamina of endothelial
  2. Podocytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does glomerular membrane prevent from filtering?

A
  1. Large molecules: Proteins

2. Negative molecules: albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is immunofluorescence used to detect?

A
  1. Complement

2. Immunoglobulins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Components of the nephron?

A
  1. Glomeruli
  2. Prox tubule
  3. Loop
  4. Distal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where does the distal tubule pass?

A

Near the glomerulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which tubules have wider lumen?

A

Distal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What structures are not found in medulla?

A
  1. Glomeruli
  2. Proximal tubule
  3. Distal tubule
17
Q

What is found in medulla?

A
  1. Loop of henle

2. Collecting ducts

18
Q

What is found on surface of proximal tubule?

A
  • Brush border greatly increasing resorptive ability
19
Q

What is the macula densa?

A
  • Region of distal tubule that runs by glomerulus
20
Q

What is the JG apparatus?

A
  • Formed by distal tubule and afferent arteriole
  • Regulates BP and filtration rate
  • Regulates based upon distal [] of NaCl
21
Q

What is loss of glomerular slit diaphragms and appearance of a continuous layer of podocyte cytoplasm indicative of?

A

MCD

22
Q

What happens in MCD?

A

Loss of glomerular slit diaphragms and appearance of continuous layer of podocyte cytoplasm