Hist for Path: 2 Flashcards
What do afferent arterioles arise from?
Interlobular arteries
What do efferent arterioles arise from?
Glomerular capillaries
What is mesangial matrix?
- Area in glomeruli between capillaries that holds them together
What is name of smooth muscle in glomeruli that regulates blood flow and filtration?
- Mesangium
3 functions of mesangium?
- Contraction to regulate flow: smooth muscle cell
- Structural support
3 Phagocytosis
Where are the fenestrations found?
- Cell walls of endothelial cells
What does basement membrane divide?
Endocapillary: mesangial
Extracapillary: Urinary space
What is in visceral epithelium?
Podocytes
What is in between foot processes of epithelium?
Slit diaphragm
What is the glomerular filtration barrier?
“Glomerular basement membrane” made of:
- Basal lamina of endothelial
- Podocytes
What does glomerular membrane prevent from filtering?
- Large molecules: Proteins
2. Negative molecules: albumin
What is immunofluorescence used to detect?
- Complement
2. Immunoglobulins
Components of the nephron?
- Glomeruli
- Prox tubule
- Loop
- Distal
Where does the distal tubule pass?
Near the glomerulus
Which tubules have wider lumen?
Distal
What structures are not found in medulla?
- Glomeruli
- Proximal tubule
- Distal tubule
What is found in medulla?
- Loop of henle
2. Collecting ducts
What is found on surface of proximal tubule?
- Brush border greatly increasing resorptive ability
What is the macula densa?
- Region of distal tubule that runs by glomerulus
What is the JG apparatus?
- Formed by distal tubule and afferent arteriole
- Regulates BP and filtration rate
- Regulates based upon distal [] of NaCl
What is loss of glomerular slit diaphragms and appearance of a continuous layer of podocyte cytoplasm indicative of?
MCD
What happens in MCD?
Loss of glomerular slit diaphragms and appearance of continuous layer of podocyte cytoplasm
