Highlight 16 - Childhood Obesity & the Early Development of Chronic Diseases Flashcards
When T2 diabetes develops before the age of 20, the incidence of what increases?
The incidence of diabetic kidney disease and death in middle age increases dramatically, largely because of the long duration of the disease
T2 diabetes is a chronic disease closely linked with _______.
obesity; Obesity is the most important risk factor for T2 diabetes
Early development of T2 diabetes is most likely to occur in those who:
- are obese
- are sedentary
- have a family history of diabetes
In T2 diabetes, the cells become ___________
insulin-resistant – that is, the cells become less sensitive to insulin, reducing the amount of glucose entering the cells from the blood
The combination of obesity and insulin-resistance produces a cluster of symptoms, including:
high blood cholesterol and high blood pressure. This promotes the development of atherosclerosis and the early development of heart disease
The complications of diabetes can shorten __________
life expectancy
Prevention and treatment of T2 diabetes depend on ____________, which can be particularly difficult.
weight management
Explain the formation of plaques in atherosclerosis.
- The coronary arteries deliver oxygen and nutrients to the heart muscle (a healthy artery provides an open passage for the flow of blood)
- Plaques can begin to form in a person as young as 15 years
- When these arteries become blocked by plaque, the part of the muscle that they feed will die (plaques reduce blood blow. Clots can form, aggravating the problem)
What is atherosclerosis?
a type of artery disease characterized by plaques (accumulations of lipid-containing material) on the inner walls of the arteries
Atherosclerosis develops when regions of _________ become progressively thickened with _______
an artery’s walls; plaque
What is plaque?
Plaque is an accumulation of fatty deposits, smooth muscle cells, and fibrous connective tissue
How do fatty streaks influence the development of atherosclerosis?
Fatty streaks may begin to accumulate fibrous connective tissues which may begin to calcify, becoming raised lesions. As the lesions begin to grow, the heart disease rate begins to rise
As __________ rises, atherosclerosis worsens.
blood cholesterol
How does blood cholesterol increase?
Blood cholesterol tends to rise as dietary saturated fat intakes increase
Blood cholesterol correlates with ________
childhood obesity, especially abdominal obesity; LDL cholesterol rises and HDL declines