High Yield Concepts

Question 1

What is cimetidine and why is it important?

Answer 1

It’s an OTC H2 blocker and a potent inducer of cyp activity. This means there will be significant interaction with other cyp-metabolized drugs, including warfarin.

Question 2

Why is rifampin & rifabutin important?

Answer 2

It’s a CYP enzyme inducer so it will interact with other CYP-metabolized drugs.

Question 3

With inflammatory liver disease, what happens to factor VIII?

Answer 3

it goes up

Question 4

What is the management/treatment of ITP?

Answer 4

steroids, and/or IVIG vs. anti-D, and/or platelet transfusion; splenectomy and/or chemo/rituximab if worsening/relapsing

Question 5

What drug(s) will Ritonavir be used to boost and how does this work?

Answer 5

lopinavir and darunavir; works because ritonavir will inhibit CYP and that means that CYP won’t metabolize the other drugs so they remain active in the serum a longer time

Question 6

What drug(s) will Cobicistat be used to boost and how does this work?

Answer 6

Cobicistat raises serum concentration of CYP3A4 substrates such as atazanavir, lopinavir, and darunavir by inhibiting CYP

Question 7

All but one HAART drug is given orally. What drug is not given orally and how is it administered?

Answer 7

Enfuvirtide - given SC

Question 8

What HAART drugs should alcohol be avoided if taking?

Answer 8

Abacavir and didanosine