High Risk Pregnancies Flashcards
Maternal conditions resulting in high risk pregnancy?
Obesity Diabetes HTN Chronic disease (renal/AI) Infections Previous surgery (adhesions) VTE
Social factors resulting in a high risk pregnancy?
Teenage pregnancy Maternal age >35 High parity and low interpregnancy interval Poor SE conditions Alcohol intake Substance abuse
Obstetric issues in previous pregnancy resulting in high risk pregnancy?
Caesarean section Preterm delivery Recurrent miscarriage Stillbirth Pre-eclampsia Gestational diabetes Third degree perineal tear
Problems in this pregnancy resulting in high risk pregnancy?
Multiple pregnancy Small for dates Placenta praevia Gestational diabetes Pre-eclampsia
Problems during labour resulting in high risk pregnancy?
Meconium/blood stained liquor
Worrying CTG
Need for oxytocin infusion
Lack of progress
Actions if pregnancy deemed high risk?
Consultant-led care
Counselling - mode of delivery, weight Special investigations - GTT Ultrasound scans - growth scans Specialised clinics - i.e. diabetic Anaesthetic reviews - BMI Close observation - BP, diabetes, urine etc.
Maternal risk factors for IUGR?
- Smoking, poor nutrition (social class)
- High altitude
- Pre-existing renal, cardiac, vascular disease
- Pregnancy related disease: Hypertension/pre-eclampsia = small babies
Foetal risk factors for IUGR?
- Nutrition – abnormal placenta development
- Teratogenic – tobacco, narcotics, alcohol, medication
- Infection – rubella, CMV, measles
Two things that encompass ‘small for gestational age’ and how to diferentiate?
- Constitutionally small - Mum is small, From an ethnic group that produces small baby
- Intrauterine growth restriction (IUGR) - Placental insufficiency. Higher risk of still birth .
To differentiate, repeat scan in 2 weeks
If continues to grow then probably constitutionally small
If plateau or tail off in growth may be IUGR and placental insufficiency.
Monitoring in IUGR?
- Symphysis-fundal height – should match number of weeks +/- 2 or 3 cm
- USS for foetal measurements
- Abdominal circumference, head circumference, femur length
- Beware head sparing (relatively large head to abdominal circumference) – could be sign of IUGR as blood/oxygen going to the brain and neglecting the abdomen due to insufficiency of placenta
Liquor volume and umbilical artery doppler in IUGR monitoring?
LIQUOR - Happy babies produce urine as they have a normal blood supply to the abdomen rather than head sparing = normal liquor volume
DOPPLER - shows resistance of the placenta (SD ratio) (want low resistance) - Look to see if there is end diastolic pressure.
• In a low resistance, healthy placenta, blood will continue to flow in diastole as well, so baby is constantly oxygenated (will always be blood flow above zero)
o Absent end diastolic flow (EDF): with a high resistance placenta, there will be no flow to baby during diastole
o Reversed EDF: In very unhealthy placenta, flow may even reverse and the baby will be losing blood and oxygen - VERY BAD
Management of IUGR?
Weekly umbilical artery doppler
Daily CTG if doppler abnormal
Delivery at 37 weeks or earlier if foetal/maternal compromise
Incidence of multiple pregnancy?
1%
What is the main factor in determining multiple pregnancy outcome?
Chorionicity
What do you look for on ultasound to determine chorionicity?
Lamda sign = Y sign that signifies dichorionicity
T-sign = monochorionic
Division times of identical twins in relation to chorionicity?
Morula - Day 1-3 - DC/DA
Blastocyst - Days 4-8 - MC/DA
Implanted blastocyst - days 8-13 - MA/MA
Formed embryonic disc - days 13-25 - conjoined twins
Maternal complications of multiple pregnancy?
Hyperemesis gravidarum, anaemia, pre-eclampsia, gestational diabetes, operative delivery, preterm labour
Foetal complications relating to all multiple pregnancies?
↑morbidity+mortality – miscarriage, preterm labour, IUGR, antepartum haemorrhage, chromosomal/structural abnormalities
Complications in monochorionic twins?
Congenital abnormalities, twin-twin-transfusion syndrome, IUGR even more common
Antenatal care in multiple pregnancy?
• USS at 11-14 weeks
• Oral Iron and Folic acid 5mg
• Detailed anatomy scan and cardiac scans
• Regular serial growth scans
o DCDA 4 weekly (from 24 weeks)
o MC twins 2 weekly (from 16 weeks)
• Regular BP and urine checks – increased surveillance for pre-eclampsia, diabetes and anaemia.
Timing and mode of delivery in multiple pregnancy?
- DCDA = 37-38 weeks
- MCDA = 34-37 weeks (MCMA = 34 weeks by CS)
- Presenting twin (one closest to cervix) = cephalic –> Vaginal delivery recommended
- Presenting twin = breech/transverse lie –> Caesarean section
What is TTTS?
15% of all MC twins – unequal blood distribution in shared placenta leading to discordant blood volumes, liquor and growth.
Diagnosing TTTS? Complications?
Diagnosis = discordant liquor volumes, recipient twin larger, polyhydramnios, fluid overload, heart failure, donor twin smaller, ‘stuck’ with oligohydramnios.
Complications = late miscarriage an severe preterm delivery, in utero death, neurological damage.
Management and prognosis of TTTS?
Management = USS surveillance from 12 weeks (every fortnight). Laser therapy if TTTS diagnosed.
Prognosis = v poor if untreated – 60% both survive, 80% one survives.
How does BP change in pregnancy?
Goes down in 1st trimester, then up in 2nd and 3rd trimesters
What is pre-eclampsia?
Hypertension and proteinuria in 2nd half of pregnancy, usually with oedema
What is the pathophysiology of pre-eclampsia?
Reduced placental bloodflow –> inflammatory response.
Endothelial cell damage –> increased vascular permeability, vasoconstriction and coagulopathy
Only cured by delivery
Risk factors for pre-eclampsia?
Nulliparity Previous history, FH Older maternal age Chronic hypertension Diabetes Twin pregnancies Autoimmune disease Renal disease Obesity
Screening and prevention of pre-eclampsia?
High-risk pregnancies screened - uterine artery doppler, sFlt-1, VEGF
Prevention - 75mg aspirin OD
Degrees of pre-eclampsia?
Mild = Proteinuria and hypertension <170/110
Moderate = Proteinuria and hypertension >170/110
Severe = Proteinuria and hypertension <32weeks or with maternal complications
Clinical features of pre-eclampsia?
History - Usually asymptomatic. At late stage –> headache, drowsiness, visual disturbances, nausea/vomiting, epigastric pain
Examination - Hypertension = first sign usually. Oedema may be massive. Epigastric tenderness. Protein in urinalysis
Maternal complications of pre-eclampsia? (indications for delivery)
Eclampsia CVA HELLP syndrome – Haemolysis, elevated liver enzymes, low platelet count DIC Liver failure Renal failure Pulmonary oedema