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Cardiovascular system > High risk drugs > Flashcards

High risk drugs Flashcards

1
Q

Amiodraone dosing

A

200mg TDS
200mg BD
200mg OD

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2
Q

Amiodarone side effects

A 
Hepatotoxic 
Pulmonary toxicity 
Thyroid toxicity 
corneal micro-deposits- dazzled by light
Photo-toxic 
Greying of the skin

Test Chest Xray, LFT, TFT, 6 monthly

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3
Q

Amiodarone interactions

A

Amiodarone is an enzyme inhibitor: raises blood conc of
Digoxin
Warfarin
Phenytoin

Grapefruit juice is an enzyme inhibitor- increased Amiodarone concentration

Increased risk of myopathy when given with statins

Bradycardia, AV Block, Myocardial depression:
BB, Rate limiting CCB (e.g. verapamil and diltiazem)

Increased risk of QT when given with Quinolone, Macrolides, Mefloquine, Chloroquine, TCA, SSRI, Lithium, Quinine, Hydroxyqloroquine, Antipsychotics(Haloperidol, pimozide/Amisulpride)

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4
Q

Digoxin is what class

A

Cardiac glycoside

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5
Q

How often to measure blood conc after Digoxin dose

A

6 hours after

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6
Q

Digoxin Signs of toxicity

A 
Bradycardia 
Yellow/Blurred vision 
Hypokalaemia 
N&V 
Confusion
Rash

Hypokalaemia, Hypercalcaemia, Hypomagnesia, renal impairment

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7
Q

Digoxin interactions

A 
CCB
Rifampicin 
Amiodarone 
St johns wort 
Erythromycin
Diuretics

Hypokalaemia: diuretics, B agonists and theophyline

Increased plasma concs of digoxin with enzyme inhibitors:
Amiodarone(half digoxin dose), CCB, Macrolides, Ciclosporin

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8
Q

Warfarin colours

A

0.5 is white
1mg brown
3mg blue
5mg pink

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9
Q

Warfarin MHRA warnings

A

Increased risk of bleeds
Antiretrovirals Hep C and Vit K antagonists- monitor INR
OTC interaction miconazole and warfarin
Calciphylaxis

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10
Q

Lithium conc

A

0.4-1mmol
0.8-1mmol in acute mania
Take levels 12 hours post dose

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11
Q

lithium complications

A 
Thyroid disorders 
Visual disturbances 
Nephrotoxic 
GI disturbances 
Polyuria 
Fine tremor 
CNS disturbances 
PRIADEL CAN GIVE VOLATILE TREMOR 
POLYURIA 
CNS DISTURBANCES 
GI DISTURBANCES 
VISUAL DISTURBANCES 
FINE TREOMOR 
Renal
EPS
Visual 
Nephrotoxic 
Nervous system 
GI
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12
Q

Monitoring requirments lithium

A 
TFT 
RFT 
U&E 
FBC 
EGC 
BMI
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13
Q

Lithium interactions

A

NSAIDS/ACEI/ARBS- reduced renal excretion
Lower seizure threshold
QT
Hyponatraemia- SSR, CArba, Diuretics, TCA

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Cardiovascular system (3 decks)

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