High Grade Glioma Flashcards
1
Q
Three types of high grade gliomas in pediatrics
A
Diffuse midline glioma
Anaplastic astrocytoma
Glioblastoma multiforme
2
Q
Molecular features associated with Diffuse midline gliomas
A
H3.3K27 - most common
H3.1 K27 - slightly less bad
3
Q
Molecular features of GBM
A
Histone mutations H3.3G34
Tp53 and ATRX mutations
MGMT promotor methylation
IDH mutant - more common in adults
4
Q
Three classic clinical features of DIPG
A
Ataxia
Long trace signs
Cranial nerve palsies
5
Q
Imaging features of DIPG
A
Expand the pond Flat fourth ventricle sign Encircle basilic artery Ring enhancing necrosis sometimes Hypointense on T1, hyper intense T2
6
Q
Factors associated with longer PFS in DIPG
A
Younger age < 3 yo
Longer duration of symptoms
H3.1 k27 mutant
7
Q
Genetic syndromes predisposing to HGG ( GBM)
A
Li fraumeni
Turcot syndrome
NF1
8
Q
Prognostic features in GBM
A
IDH mutant do better H3.2 G34 do worse MGMT promoter methylation predicts response to temozolamide Complete surgical resection Younger age do better
