Hexokinase vs Glucokinase Flashcards
Has a considerably higher Km (lower affinity) for glucose
Glucokinase
Present in most tissue
Hexokinase
Its activity increases with increases in the concentration of glucose in the hepatic portal vein
Glucokinase
Can phosphorylate glucose and other hexoses
Both Hexokinase and Glucokinase
It acts to ensure an adequate rate of glycolysis to meet the liver’s needs
Hexokinase
Present only in liver parenchymal cells and Islet cells of the pancreas
Glucokinase
Has a low Km for glucose
Hexokinase
High Vmax (Many enzymes) and Km (low affinity)
Glucokinase
In the liver it is saturated and acting at a constant rate under all normal conditions
Hexokinase
Liver activity induced by insulin
Glucokinase