Herpesviruses

Question 1

Structure

Answer 1

Double Stranded DNA
Icosahedral Capsid
Enveloped

Question 2

Hallmarks of Herpes infections

Answer 2

1) Latency-can go lytic but normally stay hidden, recurrent symptoms
2) Ubitiquous

Question 3

Site of Latency each Herpes Viruses

Answer 3

HSV1= Neuron, Alpha
HSV2=Neuron, Alpha
VZV=Neuron, Alpha
EBV=B Lymphocyte, Gamma
CMV=Monocytes and Lymphocytes, Beta
HHV6=T Lymps, Beta
HHV7&8=T Lymphs, Beta

Question 4

Epidemiology

Answer 4

70-95% of all adults are infected with a herpes virus, on 15% show symptoms

Question 5

HSV 1&2

Answer 5

Transmission=Direct Contact
Direct Cytopathology= Lesions
-Use Latency
-Cell to Cell Spread
-Reactivates from latency by stress or immunosuppression

Question 6

Oral Herpesvirus

Answer 6

Eczema Herpeticum-
Gingivostomatitis-LESIONS in area of TRIGEMINAL NERVE
-only 15% of infected have lesions
-LESIONS DO NOT SCAR
Herpes Encephalitis- MAJOR CONCERN! head CT, —>Temporal evidence
Herpes Keratoconjunctivitis- eye infection, LEADING CAUSE OF BLINDNESS

Question 7

Genital Herpes

Answer 7

Often ASYMPTOTIC

• lesions over vagina, or penis
• SEVERE PAIN on Urination

Question 8

Neonatal Herpes

Answer 8

Frequently fatal

Survivors often have brain involvement

Question 9

Diagnosis of Herpes

Answer 9

NEED Clinical Picture

• use pap or Tzanck Smear or
• fluid from herpes lesions is collected and used to infect culture cells to observe CPE, then monoclonal abs are used on the culture

Question 10

Treatment of HSV1-2

Answer 10

5-iodo-2-deoxyuridine-inhibits viral DNA poly

Adenine Arabinose- analogue of adenine, interferes with viral DNA synth

Question 11

What anitvirals block guanosine uptake?

Answer 11

Acyclovir
Valtrex
Famcyclovir