Anti-Parasites

Question 1

Antimalarial Therapy

Answer 1

1) Prophylaxis

2) Treat active infection in blood or hypnozoite in liver

Question 2

Drugs used for Prophylaxis

Answer 2

Chloroquine
and Primaquine
NO REGIMENT IS FULLY PROTECTIVE

Question 3

Drugs used for Blood treatment

Answer 3

Chloroquine and Artemisins

Question 4

Drugs used for latent hypnozoite treatment LIVER

Answer 4

Primaquine—>Vivax and Ovale

Question 5

Chloroquine

Answer 5

Blood Stage/Prophylactic
Cause accumulation of hematin–>toxic to parasite
INEFFECTIVE AGAINST most Falciprum strains in Afr, Asia, SAmerica

Adverse Rxn:Itch
Cardiotoxic

Question 6

Artemether

Answer 6

Short halflife
Not used in Prophylaxis
USED IN COMBO with LUMEFANTRINE to sustain activity
FIRST LINE ORAL TREATMENT IN MDR Falciprum areas
Treats severe malaria

Adverse:Neuro and Embryo tox in anumals

Question 7

Primaquine

Answer 7

attack hypnozoite of viax and ovale
GIVEN with Chloroquine
GIVEN as prophylaxis before or after travel to vivax/ovale regions

Question 8

Main Protozoans seen in the US

Answer 8

1) Trichomoniasis(STD)
2) Giardiasis (GI)
3) Amebiasis (GI)–>can go to the liver
4) Cryptosporidiosis

Question 9

Metronidazole

Answer 9

Anerobic bacts, Giardia, Tric, and Amebebiasis
Prodrug–>becomes DNA damager
GIVEN WITH LUMINAL PAROMOMYCIN for SEVERE AMBEBIASIS

Question 10

Paromomycin

Answer 10

Luminal clearance
binds 30S ribosomal subunit,

give during Preg

Question 11

Helminthiasis

Answer 11

often ingested as eggs/larvae in contaminated water or from the soil to skin

Taenia Solium–>Neurocysticercosis