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Year 3 - Infectious Disease > Herpes - MedEd > Flashcards

Herpes - MedEd Flashcards

1
Q

How many human herpes viruses are there?

A

8

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2
Q

List the names of all 8 HHV

A 
1 - HSV 1 
2 - HSV 2
3 - Varicella zoster 
4 - EBV
5 - CMV 
6 + 7 - HHV 6+7
8 - HHV8 (kaposi)

How hens vary every chosen Haribo has (baffled me like) kaposi

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3
Q

Is HSV DNA or RNA

A

DNA virus

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4
Q

Presentation of HSV 1

A 
Gingivostomatitis 
Temporal lobe encephalitis
Herpes labialis (on lips)
Keratoconjunctivitis 
Herpetic whitlow
Eczema herpeticum
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5
Q

What is the name for vesicles of herpes on fingers?

A

Herpetic whitlow

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6
Q

What is the name for herpes cold sores on the mouth?

A

Herpes labialis (on lips)

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7
Q

Presentation of HSV 2

A 
Painful vesicular lesions on genitals
Discharge
Urethral discharge
Dysuria (painful urination)
Fever and malaise
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8
Q

Is HSV2 acute or chronic?

A

Chronic

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9
Q

What are the two phases of HSV

A

Latent and lytic phase

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10
Q

Where does the HSV rest during latent phase?

A

Latent phase - dormant phase where HSV travels to trigeminal root ganglia or sacral root ganglia

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11
Q

What happens during the lytic phase of HSV and what triggers this?

A

Virus travels back to skin and replicates, triggered by stress or immunocompromise

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12
Q

Treatment of HSV

A

Topical, oral or IV acyclovir

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13
Q

When is VSZ contagious?

A

48 hr before vesicles

Until vesicles have crusted over (1 wk)

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14
Q

How long does shingles take to improve?

A

2 w

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15
Q

What precedes the dermatomal rash in shingles?

A

Tingling

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16
Q

Treatment for chicken pox in children

A

Calamine lotion
Analgesia
Antihistamines

17
Q

Treatment for chicken pox in adults

A

Aciclovir if within 24 hr of rash

18
Q

Treatment for shingles

A

Valaciclovir or famciclovir

Aciclovir if within 72hr of appearance of rash for 7 days

19
Q

Who is eligible for the varicella vaccine?

A

Immunosuppressed patients

Pregnant women

20
Q

Shingles epidemiology

A

Over 50s if stressed and immunocompromised

21
Q

What do you call the pain in shingles?

A

Postherpetic neuralgia

22
Q

Presentation of infectious mononucleosis

A 
Pharyngitis
Lymphadenopathy of posterior cervical nodes 
Splenomegaly and jaundice
Fever
Atypical lymphocytes
23
Q

Epidemiology of EBV

A

Affects most people

Spready by saliva/resp droplets

24
Q

Which cells does EBV affect?

A

B lymphocytes - in cooperates viral DNA into host DNA

25
Q

Investigations for EBV

A

Atypical lymphocytosis
Heterophile antibodies - monospot test (but not specific)
EBV specific antibodies (more specific)
Real time PCR for EBV DNA detection

26
Q

Management of EBV

A

Paracetamol/ibuprofen

Steroids if severe

27
Q

What do you NOT give in EBV and why?

A

Amoxicillin, or ampicillin as it causes a widespread maculopapular rash

28
Q

What counts as ‘severe’ EBV?

A

Haemolytic anaemia
Severe tonsillar swelling
Obstructive pharyngitis

29
Q

What are the two types of EBV antigens?

A

EBV Viral capsid antigen

EB nuclear antigen

30
Q

Outline the order of antibody production for EBV

A

EBV Viral capsid IgM (acute infection)
EBV VC IgG (past infection or infection that’s been there for a while)
EBNA IgG (past infection)

31
Q

Compare EBV with strep pyogenes

A

No splenomegaly in strep pyogenes

Anterior cervical chain lymphadenopathy in strep pyogenes whereas posterior in EBV

32
Q

How does karposi’s sarcoma present?

A

Purple rash

33
Q

Which lung infection can people with AIDS get?

A

Pneumocystis pneumonia

34
Q

Ring enhancing lesions on CT head - what’s the organism?

A

Toxoplasma gondii

35
Q

Bacterial vs viral tonsillitis

A

Bacterial - symptoms more severe

36
Q

Most common cause of sneezing and runny nose

A

Rhinoviruses

Year 3 - Infectious Disease (5 decks)

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